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前列腺癌中的组织酸性和碱性磷酸酶

Tissue acid and alkaline phosphatase in prostatic carcinoma.

作者信息

Erkan I, Remzi D, Ciliv G

出版信息

J Surg Oncol. 1980;13(4):341-5. doi: 10.1002/jso.2930130410.

DOI:10.1002/jso.2930130410
PMID:6154841
Abstract

Twenty-eight patients admitted with infravesical obstruction symptoms were studied. Fourteen of these patients were suffering from prostatic carcinoma defined as inoperable. The remaining 14 patients were diagnosed as benign prostatic hyperplasia (BPH) and transurethral resection (TUR) was performed to all of them. Specimens obtained by TUR were used to analyze tissue activities of total and tartarate labil acid phosphatase, and alkaline phosphatase. Enzymatic levels in the tissue were estimated by using fluorimetric method (FU/mg). The estimated averages seemed to vary in favor of the malignant tissue, however this variation was not found to be statistically significant. Different inhibition levels were observed in benign and malignant tissue with the addition of L(+) tartarate. The average levels of the alkaline phosphatase were found to be lower than those of acid phosphatase, but the former showed no difference between the malignant and benign groups.

摘要

对28例因膀胱颈以下梗阻症状入院的患者进行了研究。其中14例患者患有被定义为无法手术的前列腺癌。其余14例患者被诊断为良性前列腺增生(BPH),并对他们全部进行了经尿道切除术(TUR)。通过TUR获得的标本用于分析总酸性磷酸酶、酒石酸不稳定酸性磷酸酶和碱性磷酸酶的组织活性。采用荧光法(FU/mg)估算组织中的酶水平。估算的平均值似乎对恶性组织有利,但未发现这种差异具有统计学意义。加入L(+)酒石酸后,在良性和恶性组织中观察到不同的抑制水平。发现碱性磷酸酶的平均水平低于酸性磷酸酶,但前者在恶性和良性组之间没有差异。

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2
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