Copland G T, Whitehurst G B, Pretlow T P, Boohaker E A, Bartolucci A A, Pretlow T G
Cancer. 1983 Jul 1;52(1):155-60. doi: 10.1002/1097-0142(19830701)52:1<155::aid-cncr2820520128>3.0.co;2-j.
Acid phosphatase activity biochemically in the primary tumor of 20 patients with prostatic carcinoma, was studied in an attempt to understand the basis for a correlation or lack of correlation between serum and/or bone marrow acid phosphatase levels and the presence and/or clinical behavior of prostatic carcinoma. The enzyme activity was similarly measured in 19 patients with benign prostatic hyperplasia as controls. On the average, enzyme activities were lower (P less than 0.002) in the tissues from patients with carcinoma. There was no correlation of enzyme activity in tumor with the age of the patient, stage of disease, degree of differentiation of the tumor, or serum acid phosphatase activity.
对20例前列腺癌患者原发肿瘤的酸性磷酸酶活性进行了生化研究，旨在了解血清和/或骨髓酸性磷酸酶水平与前列腺癌的存在和/或临床行为之间相关性或缺乏相关性的基础。以19例良性前列腺增生患者作为对照，同样测定了酶活性。平均而言，癌患者组织中的酶活性较低（P<0.002）。肿瘤中的酶活性与患者年龄、疾病分期、肿瘤分化程度或血清酸性磷酸酶活性均无相关性。
