Salo J O, Rannikko S, Haapiainen R
Second Department of Surgery, Helsinki University Central Hospital, Finland.
Br J Urol. 1990 Aug;66(2):188-92. doi: 10.1111/j.1464-410x.1990.tb14901.x.
Serum acid phosphatase levels were determined in 247 men with surgically confirmed intracapsular prostatic cancer (30 patients), benign prostatic hyperplasia (BPH) (114 patients) or palpably normal prostates (103 men). Both radioimmunoassay (245 cases) and an enzymatic method (218 cases) were used. Using radioimmunoassay, the mean serum prostatic acid phosphatase (PAP) level was significantly higher in patients with BPH than in patients with intracapsular cancer or men with normal prostates. The weight of hyperplastic tissue removed during operation in the BPH group correlated closely with PAP concentrations. Age or the presence (or absence) of an indwelling catheter had no effect on PAP concentration. Using the enzymatic method, the highest levels of acid phosphatase were also detected in patients with BPH but the difference was less marked. It was concluded that intracapsular cancer does not elevate serum acid phosphatase levels as determined by radioimmunoassay or an enzymatic method. BPH alone leads to significant rises in PAP concentrations. The degree of BPH correlates with PAP levels.
对247名男性进行了血清酸性磷酸酶水平测定，这些男性经手术确诊患有前列腺包膜内癌（30例）、良性前列腺增生（BPH）（114例）或前列腺触诊正常（103例）。采用了放射免疫分析法（245例）和酶法（218例）。使用放射免疫分析法时，BPH患者的平均血清前列腺酸性磷酸酶（PAP）水平显著高于前列腺包膜内癌患者或前列腺正常的男性。BPH组手术切除的增生组织重量与PAP浓度密切相关。年龄或是否留置导管对PAP浓度无影响。使用酶法时，BPH患者的酸性磷酸酶水平也最高，但差异不太明显。结论是，根据放射免疫分析法或酶法测定，前列腺包膜内癌不会升高血清酸性磷酸酶水平。单独的BPH会导致PAP浓度显著升高。BPH的程度与PAP水平相关。
