Kirchner H, Fenkl H, Zawatzky R, Engler H, Becker H
Eur J Immunol. 1980 Mar;10(3):224-5. doi: 10.1002/eji.1830100312.
Spleen cells of homozygous nude mice did not react with lymphoproliferation to both phytohemagglutinin (PHA) and concanavalin A (Con A), and there was no detectable interferon production in response to Con A. However, PHA-induced interferon production was equal in spleen cells of nu/nu mice and nu/+ mice. One possible explanation for these findings is that a subset of T cells responds to PHA with interferon production different from that responding to Con A with interferon production.
纯合裸鼠的脾细胞对植物血凝素（PHA）和刀豆蛋白A（Con A）均无淋巴细胞增殖反应，且对Con A刺激无干扰素产生。然而，PHA诱导的干扰素产生在nu/nu小鼠和nu/+小鼠的脾细胞中是相同的。对这些发现的一种可能解释是，T细胞的一个亚群对PHA产生的干扰素反应不同于对Con A产生的干扰素反应。
