产生硫链丝菌素、西omycin和孢子丝菌素的放线菌对这些物质的抗性。
Resistance to thiostrepton, siomycin, and sporangiomycin in actinomycetes that produce them.
作者信息
Thompson J, Cundliffe E
出版信息
J Bacteriol. 1980 May;142(2):455-61. doi: 10.1128/jb.142.2.455-461.1980.
Abstract
The antibiotics thiostrepton, siomycin, and sporangiomycin are closely related both in structure and in mode of action. Actinomycetes which produce this group of compounds possess ribonucleic acid-pentose methylases, which act upon 23S ribosomal ribonucleic acid and render ribosomes resistant to the action of these antibiotics. This is achieved via the formation of a single residue of 2'-O-methyladenosine per ribosome.
摘要
抗生素硫链丝菌素、西霉素和孢子囊霉素在结构和作用方式上密切相关。产生这类化合物的放线菌具有核糖核酸-戊糖甲基化酶，该酶作用于23S核糖体核糖核酸，使核糖体对这些抗生素的作用产生抗性。这是通过每个核糖体形成一个2'-O-甲基腺苷残基来实现的。
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