孢子丝菌素和小球菌素对核糖体A位点功能的抑制作用。
Inhibition of ribosomal A site functions by sporangiomycin and micrococcin.
作者信息
Cundliffe E, Dixon P D
出版信息
Antimicrob Agents Chemother. 1975 Jul;8(1):1-4. doi: 10.1128/AAC.8.1.1.
Abstract
Sporangiomycin and micrococcin inhibit the binding of aminoacyl-transfer ribonucleic acid into the ribosomal A site in intact bacterial protoplasts. They also prevent the assembly of [ribosome-elongation factor G-guanine nucleotide] complexes in vitro and compete with [(35)S]thiostrepton for ribosomal binding sites. We conclude that micrococcin and sporangiomycin block the ribosomal A site in the vicinity of the complex guanosine triphosphatase center and so resemble thiostrepton in their modes of action.
摘要
孢子丝菌素和微球菌素可抑制氨酰转移核糖核酸在完整细菌原生质体中与核糖体A位点的结合。它们还能在体外阻止[核糖体-延伸因子G-鸟嘌呤核苷酸]复合物的组装，并与[(35)S]硫链丝菌素竞争核糖体结合位点。我们得出结论，微球菌素和孢子丝菌素在复合鸟苷三磷酸酶中心附近阻断核糖体A位点，因此它们的作用方式类似于硫链丝菌素。
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