色甘酸钠对多种药理刺激物诱导的豚鼠回肠收缩的保护作用。

A protective action of disodium cromoglycate against the contraction of guinea-pig ileum induced by various pharmacological stimulants.

作者信息

Kazimierczak W, Gonzalez Alvarez R, Maśliński C

出版信息

Agents Actions. 1980 Apr;10(1 Pt 2):8-14. doi: 10.1007/BF02024172.

DOI:10.1007/BF02024172

Abstract

The effect of disodium cromoglycate (DSCG) on the contraction of isolated guinea-pig ileum induced by histamine, acetylcholine and serotonin has been investigated. DSCG protected ileum against all agents tested. The action of DSCG at concentrations of 10(-3) to 10(-2) M was both dose- and time-dependent. Furthermore, DSCG inhibited compound 48/80-induced histamine release from isolated mast cells over the same range of concentrations. The anti-histaminic action of DSCG was reversible and after 2 h the ileum responded normally to histamine. DSCG-induced inhibition of the contractile response to histamine could be overcome by increasing concentrations of histamine but not by extracellular calcium. A mechanism of the action of DSCG, either against the contraction of ileal smooth muscle or against histamine release from mast cells, is discussed with a view to the inhibition of the utilization of calcium ions by both cells.

摘要

已研究了色甘酸钠（DSCG）对组胺、乙酰胆碱和5-羟色胺诱导的豚鼠离体回肠收缩的影响。DSCG对所有测试药物均能保护回肠。DSCG在10⁻³至10⁻²M浓度下的作用呈剂量和时间依赖性。此外，DSCG在相同浓度范围内抑制化合物48/80诱导的离体肥大细胞组胺释放。DSCG的抗组胺作用是可逆的，2小时后回肠对组胺反应正常。增加组胺浓度可克服DSCG诱导的对组胺收缩反应的抑制，但细胞外钙不能。本文讨论了DSCG作用的机制，即其对回肠平滑肌收缩或肥大细胞组胺释放的作用，旨在抑制两种细胞对钙离子的利用。