某些膜稳定药物对组胺诱导的豚鼠回肠收缩的影响。

Effect of some membrane stabilizing drugs on histamine-induced contraction of guinea pig ileum.

作者信息

Alvarez R G, Kazimierczak W

出版信息

Arch Immunol Ther Exp (Warsz). 1980;28(6):911-5.

Abstract

The effect of disodium cromoglycate (DSCG), pyridoxine and procaine on histamine-induced contraction of isolated guinea pig ileum was investigated. The antiallergic drug DSCG exerted a protective action on ileum against histamine either when it was present or after it was washed out. Procaine, a local anesthetic exerted a similar pharmacological action on ileum to that of DSCG. On the other hand, pyridoxine protected guinea pig ileum against histamine only when it was present in the bath and this effect quickly disappeared after removing of pyridoxine. The mechanism of action of both DSCG and procaine is discussed in relation to their membrane stabilizing effect and inhibition of calcium transport, whereas effect of pyridoxine resembled to some extent, the action of theophylline.

摘要

研究了色甘酸钠（DSCG）、吡哆醇和普鲁卡因对组胺诱导的豚鼠离体回肠收缩的影响。抗过敏药物DSCG在存在时或冲洗掉后均对回肠发挥抗组胺保护作用。局部麻醉药普鲁卡因对回肠发挥与DSCG类似的药理作用。另一方面，吡哆醇仅在浴液中存在时保护豚鼠回肠免受组胺影响，去除吡哆醇后这种作用迅速消失。讨论了DSCG和普鲁卡因的作用机制与其膜稳定作用和钙转运抑制的关系，而吡哆醇的作用在一定程度上类似于茶碱的作用。