小鼠肿瘤生长过程中干扰素及其他淋巴因子的产生。I. 大鼠扎伊德拉斯腹水肝癌细胞游离液中的淋巴因子。
Production of interferon and other lymphokines during murine tumour growth. I. Lymphokines in cell--free fluid of rat Zajdela ascites hepatoma.
作者信息
Zschiesche W, Fahlbusch B, Schumann I, Lackovic V, Borecký L
出版信息
Acta Virol. 1980 Jan;24(1):37-44.
Cell-free ascites of rat Zajdela hepatoma was assayed for the presence of lymphokine-like factors. Macrophage migration inhibitory and microbial growth inhibitory cytokines were detected with peak activities at day 4-8 and 10-11 after tumour inoculation, respectively. Occasionally, skin reactive activity was found, whereas only borderline titres of an interferon-like substance were demonstrated. Preliminary studies indicated that both migration inhibitory and microbial growth inhibitory factors are proteins resembling the corresponding lymphocyte-derived lymphokines. The cellular site of formation of these factors remains to be determined.
对大鼠Zajdela肝癌的无细胞腹水进行检测，以确定是否存在类淋巴因子。分别在接种肿瘤后的第4 - 8天和第10 - 11天检测到巨噬细胞移动抑制和微生物生长抑制细胞因子的活性峰值。偶尔会发现皮肤反应活性，而仅显示出类似干扰素物质的临界效价。初步研究表明，移动抑制因子和微生物生长抑制因子都是类似于相应淋巴细胞衍生淋巴因子的蛋白质。这些因子的细胞形成部位尚待确定。
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