• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Effect of adriamycin on the polyribosome and messenger-RNA content of rat heart muscle.

作者信息

Zähringer J, Höfling B, Raum W, Kandolph R

出版信息

Biochim Biophys Acta. 1980 Jul 29;608(2):315-23. doi: 10.1016/0005-2787(80)90177-x.

DOI:10.1016/0005-2787(80)90177-x
PMID:6156705
Abstract

The myocardial contents of DNA, protein, total and polyribosomal RNA, messenger RNA (mRNA) and polyribosomes were determined in normal and adriamycin-treated rats. While the myocardial contents of DNA and protein changed only little in adriamycin-treated rats, total and polyribosomal RNA decreased by 23.2% and 35%, mRNA and polyribosomes by 51.6% and 38.7%. Size distribution and protein synthetic activity of the polyribosome preparations obtained remained unchanged in the adriamycin-treated rats. We conclude that the reduced myocardial contents of RNA, mRNA and polyribosomes cause the previously observed impairment of myocardial protein synthesis in adriamycin-treated rats and might be important in the pathogenesis of the adriamycin-cardiomyopathy.

摘要

相似文献

1
Effect of adriamycin on the polyribosome and messenger-RNA content of rat heart muscle.
Biochim Biophys Acta. 1980 Jul 29;608(2):315-23. doi: 10.1016/0005-2787(80)90177-x.
2
The regulation of protein synthesis in heart muscle under normal conditions and in the adriamycin-cardiomyopathy.正常条件下以及阿霉素诱导的心肌病状态下心肌中蛋白质合成的调控
Klin Wochenschr. 1981 Dec 1;59(23):1273-87. doi: 10.1007/BF01711177.
3
Decrease of myocardial mRNA in adriamycin-treated rats.
FEBS Lett. 1981 Jan 26;123(2):169-72. doi: 10.1016/0014-5793(81)80279-7.
4
[Gene expression and protein synthesis in the normal heart muscle and in adriamycin cardiomyopathy].
Fortschr Med. 1983 May 5;101(17):805-7.
5
In vivo RNA synthesis of the hearts of adriamycin-treated rats.阿霉素处理大鼠心脏的体内RNA合成
Cancer Res. 1982 Jan;42(1):79-83.
6
Studies on the intracellular segregation of polyribosome-associated messenger ribonucleic acid species in the lactating guinea-pig mammary gland.泌乳豚鼠乳腺中多核糖体相关信使核糖核酸种类的细胞内分离研究。
Biochem J. 1979 Sep 1;181(3):737-56. doi: 10.1042/bj1810737.
7
[Effect of adriamycin on expression and content of myocardial structural and regulatory proteins].[阿霉素对心肌结构蛋白和调节蛋白表达及含量的影响]
Kardiologiia. 2002;42(9):60-6.
8
The proportion of ribosomes active in protein synthesis and the content of polyribosomal poly(A)-containing RNA in adult and senescent rat livers.成年和衰老大鼠肝脏中参与蛋白质合成的核糖体比例以及多核糖体含聚腺苷酸RNA的含量。
Gerontology. 1979;25(6):322-6. doi: 10.1159/000212360.
9
Acute doxorubicin (adriamycin) dosage does not reduce cardiac protein synthesis in vivo, but decreases diaminopeptidase I and proline endopeptidase activities.急性阿霉素（阿霉素）剂量在体内不会降低心脏蛋白质合成，但会降低二氨基肽酶I和脯氨酸内肽酶活性。
Exp Mol Pathol. 2001 Apr;70(2):154-61. doi: 10.1006/exmp.2000.2353.
10
Acute effects of ethanol intake on albumin and total protein synthesis in free and membrane-bound polyribosomes of rat liver.乙醇摄入对大鼠肝脏游离及膜结合多核糖体中白蛋白和总蛋白合成的急性影响。
Biochim Biophys Acta. 1981 Sep 28;655(2):119-27. doi: 10.1016/0005-2787(81)90001-0.

引用本文的文献

1
Detection of adriamycin-induced cardiotoxicity in cultured heart cells with technetium 99m-SESTAMIBI.用锝99m-甲氧基异丁基异腈检测阿霉素诱导的培养心肌细胞的心脏毒性。
Cancer Chemother Pharmacol. 1993;32(5):385-91. doi: 10.1007/BF00735924.
2
Acute negative inotropic effect of adriamycin (doxorubicin).阿霉素（多柔比星）的急性负性肌力作用。
Naunyn Schmiedebergs Arch Pharmacol. 1981 Nov;317(3):252-6. doi: 10.1007/BF00503826.
3
The effect of adriamycin on Z-DNA formation and DNA synthesis.阿霉素对Z-DNA形成及DNA合成的影响。
Nucleic Acids Res. 1983 Dec 10;11(23):8415-20. doi: 10.1093/nar/11.23.8415.
4
The regulation of protein synthesis in heart muscle under normal conditions and in the adriamycin-cardiomyopathy.正常条件下以及阿霉素诱导的心肌病状态下心肌中蛋白质合成的调控
Klin Wochenschr. 1981 Dec 1;59(23):1273-87. doi: 10.1007/BF01711177.
5
Inhibition of transcription by adriamycin is a consequence of the loss of negative superhelicity in DNA mediated by topoisomerase II.阿霉素对转录的抑制作用是由拓扑异构酶II介导的DNA负超螺旋性丧失的结果。
Mol Cell Biochem. 1990 Mar 27;93(2):141-6. doi: 10.1007/BF00226185.
6
Anthracyclines selectively decrease alpha cardiac actin mRNA abundance in the rat heart.蒽环类药物选择性降低大鼠心脏中α心肌肌动蛋白mRNA丰度。
Am J Pathol. 1992 Nov;141(5):1187-95.
7
Polyoxyethylene-modified superoxide dismutase reduces side effects of adriamycin and mitomycin C.聚氧乙烯修饰的超氧化物歧化酶可降低阿霉素和丝裂霉素C的副作用。
Jpn J Cancer Res. 1992 Aug;83(8):899-906. doi: 10.1111/j.1349-7006.1992.tb01997.x.