阿霉素对Z-DNA形成及DNA合成的影响。
The effect of adriamycin on Z-DNA formation and DNA synthesis.
作者信息
Van Helden P D
出版信息
Nucleic Acids Res. 1983 Dec 10;11(23):8415-20. doi: 10.1093/nar/11.23.8415.
Abstract
The ability of adriamycin to inhibit Z-DNA formation induced by a high-salt environment was investigated. ADM inhibited this conversion, such that in poly (dG-dC) total inhibition was observed at 1 ADM: 9 base pairs and in eukaryotic DNA (calf thymus) at 1 ADM: 11,5 base pairs. Even at low ADM concentration, 1 ADM: 160 base pairs, some inhibition was observed. At similar ADM:DNA concentrations, an inhibition in DNA synthesis in cells in culture was observed, which showed some parallel with the inhibition of Z-DNA formation. A model is proposed where Z-DNA formation precedes DNA synthesis and where inhibition of the former could explain the antineoplastic nature of adriamycin.
摘要
研究了阿霉素抑制高盐环境诱导的Z-DNA形成的能力。阿霉素抑制这种转变，使得在聚（dG-dC）中，在1个阿霉素：9个碱基对时观察到完全抑制，在真核DNA（小牛胸腺）中，在1个阿霉素：11.5个碱基对时观察到完全抑制。即使在低阿霉素浓度（1个阿霉素：160个碱基对）下，也观察到了一些抑制作用。在相似的阿霉素：DNA浓度下，观察到培养细胞中DNA合成受到抑制，这与Z-DNA形成的抑制表现出一定的平行关系。提出了一个模型，其中Z-DNA形成先于DNA合成，并且前者的抑制可以解释阿霉素的抗肿瘤性质。
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