干扰素抑制细胞表面成分的重新分布。
Interferon inhibits the redistribution of cell surface components.
作者信息
Pfeffer L M, Wang E, Tamm I
出版信息
J Exp Med. 1980 Aug 1;152(2):469-74. doi: 10.1084/jem.152.2.469.
Abstract
Interferon treatment impairs the ability of cells to redistribute cell surface receptors for concanavalin A (Con A). The effect of interferon becomes evident within 3-6 h and is maximal within 36-48 h. Highly purified human fibroblast interferon (> 2 x 10(8) U/mg of protein sp act; concentration; 640 U/ml) caused approximately 85% inhibition of capping of fluorescein-conjugated Con A in interferon-sensitive HeLa-S3 cells at 36 h from the beginning of treatment.
摘要
干扰素治疗会损害细胞重新分布伴刀豆球蛋白A（Con A）细胞表面受体的能力。干扰素的作用在3 - 6小时内变得明显，并在36 - 48小时内达到最大值。高度纯化的人成纤维细胞干扰素（比活性> 2 x 10(8) U/mg蛋白质；浓度为640 U/ml）在治疗开始36小时后，对干扰素敏感的HeLa - S3细胞中荧光素偶联的Con A的帽化作用产生了约85%的抑制。
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