Holbach K H, Wassmann H, Linke D
Eur Neurol. 1977;16(1-6):213-21. doi: 10.1159/000114902.
In 13 patients with compressive spinal cord lesions we performed a trial of treatment with hyperbaric oxygen (HO). This therapy was postoperatively administered when neurological deficit persisted. In order to assess the effect of each individual HO session (given daily at an inspiratory oxygen pressure (PO2) of 1.5 atmospheres absolute for 40 min) as well as of the entire HO therapy (consisting of 10-15 single sessions in each case) neurological and electromyographical follow-up examinations were regularly performed. In 6 of the 13 patients we found a marked improvement, particularly in motor functions. The other patients only showed little change in neurological status. Arterial and cerebrospinal fluid (CSF) PO2 were concurrently measured in 8 patients during HO sessions. The values of both showed a considerable increase. The rise in CSF PO2 may be regarded as indicative for an improved oxygenation of the spinal cord tissue during HO treatment. On the basis of these findings we may assume that repetitive HO treatment can be helpful in the management of compressive spinal cord lesions.
我们对13例脊髓压迫性病变患者进行了高压氧（HO）治疗试验。当神经功能缺损持续存在时，术后给予这种治疗。为了评估每个高压氧治疗疗程（每天在1.5绝对大气压的吸入氧压（PO2）下进行40分钟）以及整个高压氧治疗（每个病例包括10 - 15个单次疗程）的效果，定期进行神经学和肌电图随访检查。13例患者中有6例有明显改善，特别是运动功能方面。其他患者神经状态仅有轻微变化。在8例患者的高压氧治疗疗程中同时测量了动脉血和脑脊液（CSF）的PO2。两者的值均有显著升高。脑脊液PO2的升高可被视为高压氧治疗期间脊髓组织氧合改善的指标。基于这些发现，我们可以认为重复高压氧治疗有助于脊髓压迫性病变的治疗。
