Chan K, Calvey T N
Eur Neurol. 1977;16(1-6):69-72. doi: 10.1159/000114882.
The urinary clearance of pyridostigmine was studied in six patients with myasthenia gravis. In three patients on pyridostigmine alone, renal clearance ranged from 349 to 481 ml/min, corresponding to a pyridostigmine:creatinine clearance ratio of 2.64 to 3.46. In a patient on bendrofluazide as well as pyridostigmine, a similar clearance ratio was observed. By contrast, the urinary clearance of pyridostigmine and the pyridostigmine:creatinine clearance ratio was reduced in two myasthenic patients concurrently treated with other basic drugs. It is suggested that these results may reflect competition for renal tubular excretion.
对六名重症肌无力患者的吡啶斯的明尿清除率进行了研究。三名仅服用吡啶斯的明的患者，其肾脏清除率在349至481毫升/分钟之间，对应的吡啶斯的明与肌酐清除率之比为2.64至3.46。一名同时服用苄氟噻嗪和吡啶斯的明的患者，观察到了类似的清除率。相比之下，两名同时接受其他碱性药物治疗的重症肌无力患者，吡啶斯的明的尿清除率以及吡啶斯的明与肌酐清除率之比降低。提示这些结果可能反映了肾小管排泄的竞争。
