在构成菌株内交叉反应独特型的抗体家族中存在高度保守的独特型决定簇。
Presence of highly conserved idiotypic determinants in a family of antibodies that constitute an intrastrain cross-reactive idiotype.
作者信息
Lamoyi E, Estess P, Capra J D, Nisonoff A
出版信息
J Exp Med. 1980 Sep 1;152(3):703-11. doi: 10.1084/jem.152.3.703.
Abstract
It has been shown that A/J anti-p-azophenylarsonate antibodies that share a major cross-reactive idiotype (CRI) comprise a family of closely related, but nonidentical, molecules. Our results demonstrate that 12 of 14 monoclonal hybridoma products that express the CRI have in common at least one highly conserved idiotypic determinant. It is proposed that this reflects conservation of a portion of the amino acid sequence, presumably in hypervariable regions. That the conserved determinant(s0 are located in the region of the hapten-binding site is indicated by the ability of haptens to inhibit idiotype-anti-idiotype interactions involving the conserved, or public determinants.
摘要
已表明，具有主要交叉反应独特型（CRI）的A/J抗对氨基苯砷酸盐抗体包含一族密切相关但并不完全相同的分子。我们的结果表明，表达CRI的14种单克隆杂交瘤产物中有12种至少具有一个高度保守的独特型决定簇。有人提出，这反映了氨基酸序列一部分的保守性，推测是在高变区。半抗原能够抑制涉及保守（或公共）决定簇的独特型-抗独特型相互作用，这表明保守决定簇位于半抗原结合位点区域。
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Presence of highly conserved idiotypic determinants in a family of antibodies that constitute an intrastrain cross-reactive idiotype.在构成菌株内交叉反应独特型的抗体家族中存在高度保守的独特型决定簇。
J Exp Med. 1980 Sep 1;152(3):703-11. doi: 10.1084/jem.152.3.703.
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An intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of BALB/c mice.与BALB/c小鼠抗对氨基苯胂酸抗体相关的株内交叉反应独特型。
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Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype.来自五种针对对氨基苯砷酸具有不同交叉反应独特型的单克隆抗体的轻链可变区的完整氨基酸序列。
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Independent regulation of serologically distinct idiotypes in F1 hybrid mice.F1 杂交小鼠中血清学上不同独特型的独立调节。
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Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.具有明确独特型特异性的诱导抗体的结构研究。IX. 来自A/J小鼠的单克隆抗对氨基苯砷酸盐抗体重链和轻链可变区在交叉反应独特型方面的框架差异。
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Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.表达A/J小鼠抗对氨基苯胂酸盐反应主要独特型的杂交瘤蛋白。
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