Morell A, Schürch B, Ryser D, Hofer F, Skvaril F, Barandun S
Vox Sang. 1980;38(5):272-83. doi: 10.1111/j.1423-0410.1980.tb02367.x.
Metabolic properties of standard gamma globulin (St-GG) and of several gamma globulin (GG) preparations for intravenous use were analyzed in radioactive tracer studies. The in vivo behaviour of St-GG was investigated in 16 probands and found to be comparable to that of normal IgG. The kinetics of the resorption of St-GG from intramuscular deposits, its elimination from the intravascular compartment and from the body were studied in 2 probands. Metabolic properties of GG preparations for intravenous use were compared with those of St-GG in 3-4 probands after simultaneous injection of 125I- and 131I-labelled tracer doses. Important differences in the half-times of intravascular survival, in the rates of catabolism and in the distribution in the body were noticed for most of the preparations for intravenous use except for an improved acid-treated (pH 4) GG, the in vivo behaviour of which was similar to that of St-GG.
在放射性示踪研究中分析了标准γ球蛋白（St-GG）和几种静脉用γ球蛋白（GG）制剂的代谢特性。在16名受试者中研究了St-GG的体内行为，发现其与正常IgG相当。在2名受试者中研究了St-GG从肌肉注射部位的吸收动力学、其从血管腔室和体内的消除情况。在同时注射125I和131I标记的示踪剂量后，在3 - 4名受试者中将静脉用GG制剂的代谢特性与St-GG的代谢特性进行了比较。除了一种经过酸处理（pH 4）的改良GG制剂外，大多数静脉用制剂在血管内存活半衰期、分解代谢速率和体内分布方面都存在显著差异，该改良GG制剂的体内行为与St-GG相似。
