Eklund J, Hermann M, Kjellman H, Pohja P
Br Med J (Clin Res Ed). 1982 Mar 20;284(6319):854-5. doi: 10.1136/bmj.284.6319.854.
Anti-D IgG was injected into 15 Rh-negative women in the 28th week of gestation and into three non-pregnant women. The uptake of anti-D after the intramuscular injections was calculated by measuring the concentration of antibody in the plasma with an autoanalyser. The biological half life and the catabolic rate of anti-D IgG were calculated according to a compartmental model. The recovery in vivo of anti-D was an average 24% in the non-pregnant women and 21% in the pregnant women. The half life of anti-D were 24 and 21 days, respectively. With a dose of 125 micrograms the plasma anti-D concentration was less than 1 ng/ml at about 10 weeks after the injection. With double the dose the concentration at delivery was at least 1 ng/ml. Although 250 micrograms of anti-D IgG seems to be effective when given in the 28th weeks of gestation, the great individual variations in uptake and recovery rates will lead to occasional cases of Rh-immunisation during pregnancy despite all routine regimens.
在妊娠第28周时，给15名Rh阴性女性和3名非妊娠女性注射了抗D IgG。通过自动分析仪测量血浆中抗体浓度来计算肌肉注射后抗D的摄取量。根据房室模型计算抗D IgG的生物半衰期和分解代谢率。非妊娠女性体内抗D的平均回收率为24%，妊娠女性为21%。抗D的半衰期分别为24天和21天。注射125微克剂量后，约10周时血浆抗D浓度低于1纳克/毫升。剂量加倍时，分娩时的浓度至少为1纳克/毫升。尽管在妊娠第28周给予250微克抗D IgG似乎有效，但摄取率和回收率的个体差异很大，尽管有所有常规方案，仍会导致孕期偶尔出现Rh免疫的情况。
