Kutti J, Zaroulis C G, Kulpa J, Reich L, Clarkson B D, Good R A
Am J Hematol. 1980;8(4):339-45. doi: 10.1002/ajh.2830080402.
Plasma beta-thromboglobulin (beta-TG) levels were measured in 14 healthy subjects and in 20 acute leukemia (AL) patients, newly diagnosed, with highly variable values for venous platelet counts. For healthy subjects the plasma beta-TG levels ranged 12-38 (mean 17) ng/ml. In this group of patients with AL, a highly significant positive correlation (P < 0.001) between the values for plasma beta-TG and venous platelet count was present. During a thrombocytopenic period, the plasma beta-TG concentraton was measured in nine of the AL patients immediately before and 10 to 12 hours after platelet transfusion therapy. Fourteen platelet transfusions were administered when the patient's highest temperature of the day was < 38.5 degrees C, and 18 when the highest temperature of the day was greater than or equal to 38.5 degrees C. The mean pre-transfusion and post-transfusion beta-TG values for the 14 platelet transfusions were 7 +/- 2 and 20 +/- 5 ng/ml, respectively. The corresponding means for the 18 transfusions given to febrile patients were 5 +/- 2 ng/ml and 11 +/- 2 ng/ml, respectively. Of the pretransfusion values, 11/14 and 14/18 were below the control range. We conclude that the plasma beta-TG values are considerably lower in thrombocytopenic patients than in subjects with normal platelet counts. Further work should provide reference values for plasma beta-TG over a wide range of venous platelet counts.
对14名健康受试者和20名新诊断的急性白血病（AL）患者进行了血浆β-血小板球蛋白（β-TG）水平测定，这些患者的静脉血小板计数差异很大。健康受试者的血浆β-TG水平在12 - 38（平均17）ng/ml之间。在这组AL患者中，血浆β-TG值与静脉血小板计数之间存在高度显著的正相关（P < 0.001）。在血小板减少期，对9名AL患者在血小板输注治疗前及治疗后10至12小时测定了血浆β-TG浓度。当患者当日最高体温<38.5℃时进行了14次血小板输注，当日最高体温≥38.5℃时进行了18次输注。14次血小板输注的输血前和输血后β-TG平均 值分别为7±2和20±5 ng/ml。发热患者的18次输注的相应平均值分别为5±2 ng/ml和11±2 ng/ml。输血前的值中，14次中有11次、18次中有14次低于对照范围。我们得出结论，血小板减少患者的血浆β-TG值明显低于血小板计数正常的受试者。进一步的研究应提供广泛静脉血小板计数范围内的血浆β-TG参考值。
