Flavonoids with antioxidant action (naringin and rutin) and the release of mastocytic and nonmastocytic histamine.

In view of the data about the antioxidant mechanism of the membrane-stabilizing action of the bioflavonoids, the participation of this mechanism in the release of histamine as well is assumed to be possible. Experiments are carried out on 35 male albino rats. The effect of the flavonoids naringin and rutin on the level of mastocytic and nonmastocytic histamine is studied, as well as on its release induced by compound 48/80 (2 mg/kg i. p.). The substances are applied intraperitonealy in doses of 200 mg/kg; corresponding to 10% DL50. The histamine content is determined fluorimetrically by the method of Schore et al. (1959). The results show that naringin and rutin have no effect on the levels of mastocytic and nonmastocytic histamine. They prevent the release of mastocytic histamine, induced by compound 48/80.