Adinolfi D, Pavesi L, Robustelli della Cuna G, Paoletti P
Riv Patol Nerv Ment. 1977 May-Jun;98(3):191-5.
This study concerns 59 patients with primary and metastatic tumors of the CNS. After surgery, each patients followed a therapeutic protocol requiring Radiotherapy (5500 Rads for 6 weeks) and antiblastic monochemotherapy with CCNU (130 MG/M2/D p.o. every 8 weeks). The results were evaluated according to Wilson's (1975) criteria of response to therapy. CCNU significantly improved the survival time in comparison to the data given for conventional treatment.
本研究涉及59例中枢神经系统原发性和转移性肿瘤患者。手术后，每位患者遵循一个治疗方案，该方案要求进行放射治疗（6周内5500拉德）以及使用环己亚硝脲进行抗瘤单药化疗（口服，130毫克/平方米/天，每8周一次）。根据威尔逊（1975年）的治疗反应标准对结果进行评估。与传统治疗给出的数据相比，环己亚硝脲显著延长了生存时间。
