通过等电聚焦检测到脑脊液免疫球蛋白成分异常。
Abnormal CSF immunoglobulin components detected by isoelectric focusing.
作者信息
Sidén A
出版信息
J Neurol. 1980;224(2):133-44. doi: 10.1007/BF00313351.
PMID:6160217
Abstract
The results from thin-layer isoelectric focusing of 4000 paired CSF and serum samples were examined for the occurrence of abnormal CSF immunoglobulin components. Such changes, not referable to serum protein abnormalities, were detected in 630 samples from 465 patients. All but 3 of these subjects had symptoms and signs of an affection of the nervous system, predominantly MS and encephalitic or myelitic/radiculitic disorders of known or presumed infectious etiology. The abnormal, microheterogeneous immunoglobulin components were mostly focused in the pI range approximately 7.5--9 with generally a shift towards pI-values > 8 pH units; a distribution differing from that of M components in plasma cell dyscrasias.
摘要
对4000对脑脊液和血清样本进行薄层等电聚焦，检测脑脊液免疫球蛋白成分异常情况。在465例患者的630份样本中检测到此类并非由血清蛋白异常所致的变化。除3例患者外，所有这些受试者均有神经系统受累的症状和体征，主要为多发性硬化症以及已知或推测为感染性病因的脑炎或脊髓炎/神经根炎疾病。异常的微不均一免疫球蛋白成分大多聚焦在大约7.5 - 9的等电点范围内，通常向等电点值>8 pH单位偏移；这种分布与浆细胞发育异常中M成分的分布不同。
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