Traugott U
J Neurol. 1978 Dec 7;219(3):185-97. doi: 10.1007/BF00314534.
Cerebrospinal fluids (CSF) from 66 patients with a variety of neurological disorders were studied for total protein content, absolute amount of albumin, IgA, IgG and IgM, as well as their quotients (fraction to total protein ratio), cell numbers and B cell and T cell levels. In addition, the percentage of B cells and T cells in the blood was determined in 34 patients and serum immunoglobulin levels were estimated in 51 patients. In noninflammatory diseases of the CNS, the percentage of B cells was slightly higher and T cell levels were lower in the CSF in comparison to corresponding blood values. The B cell to T cell ratio in viral meningitis was altered in the CSF. An apparent increase in the T cell level led to a decrease of B cell values. Similar changes were also found in optic neuritis. The percentage of T cells was higher in relapsing multiple sclerosis than in the chronic progressive form. There were less striking changes in the B cell to T cell ratios in the CSF of other inflammatory diseases of the CNS.
对66例患有各种神经系统疾病患者的脑脊液（CSF）进行了研究，检测了总蛋白含量、白蛋白、IgA、IgG和IgM的绝对量及其商值（占总蛋白的比例）、细胞数量以及B细胞和T细胞水平。此外，测定了34例患者血液中B细胞和T细胞的百分比，并评估了51例患者的血清免疫球蛋白水平。在中枢神经系统非炎性疾病中，与相应血液值相比，脑脊液中B细胞百分比略高，T细胞水平较低。病毒性脑膜炎患者脑脊液中B细胞与T细胞的比例发生了改变。T细胞水平明显升高导致B细胞值下降。视神经炎中也发现了类似变化。复发型多发性硬化症患者脑脊液中T细胞百分比高于慢性进展型。中枢神经系统其他炎性疾病患者脑脊液中B细胞与T细胞比例的变化不那么明显。
