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采用凝胶电聚焦继以电泳法分离脑脊液中的蛋白质。

Separation of the proteins of cerebrospinal fluid using gel electrofocusing followed by electrophoresis.

作者信息

Fossard C, Dale G, Latner A L

出版信息

J Clin Pathol. 1970 Oct;23(7):586-9. doi: 10.1136/jcp.23.7.586.

DOI:10.1136/jcp.23.7.586
PMID:5488785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476841/
Abstract

The technique previously applied to serum can, with minor modifications, be applied to cerebrospinal fluid. Good protein patterns have been obtained and similarities as well as differences have been demonstrated between cerebrospinal fluid and serum. The patterns obtained should prove useful in neurological diagnosis.

摘要

先前应用于血清的技术，稍作修改后即可应用于脑脊液。现已获得良好的蛋白质图谱，并证明了脑脊液与血清之间的异同。所获得的图谱应在神经诊断中证明是有用的。

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本文引用的文献

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AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS.脑脊液中蛋白质成分的电泳研究及其与血清蛋白质的关系
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The cerebrospinal fluid tau-transferrin. Isoelectric focusing study on 674 neurological patients.脑脊液tau-转铁蛋白。对674例神经系统疾病患者的等电聚焦研究。
Ital J Neurol Sci. 1980 Oct;1(4):251-5. doi: 10.1007/BF02336706.
6
Identification of the kappa and lambda light chains within the CSF immunoglobulin region in multiple sclerosis and subacute sclerosing panencephalitis by immunofixation after isoelectric focusing.通过等电聚焦后免疫固定法鉴定多发性硬化症和亚急性硬化性全脑炎患者脑脊液免疫球蛋白区域内的κ和λ轻链。
J Neurol. 1981;226(3):169-79. doi: 10.1007/BF00313378.
7
Abnormal CSF immunoglobulin components detected by isoelectric focusing.通过等电聚焦检测到脑脊液免疫球蛋白成分异常。
J Neurol. 1980;224(2):133-44. doi: 10.1007/BF00313351.
8
Intrathecal IgG synthesis in multiple sclerosis and other neurological diseases: a comparative evaluation by IgG-index and isoelectric focusing.多发性硬化症及其他神经系统疾病中的鞘内IgG合成：通过IgG指数和等电聚焦进行的比较评估
J Neurol. 1979 Oct;221(4):245-55. doi: 10.1007/BF00314641.
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J Neurol. 1979 Jul 11;221(1):39-51. doi: 10.1007/BF00313168.
4
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J Clin Pathol. 1964 Mar;17(2):143-8. doi: 10.1136/jcp.17.2.143.
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Haptoglobins in cerebrospinal fluid.脑脊液中的触珠蛋白。
Clin Chim Acta. 1963 Mar;8:202-6. doi: 10.1016/0009-8981(63)90158-x.
6
Notation for serum-protein groups and the genes controlling their inheritance.血清蛋白组的表示法及其遗传控制基因。
Nature. 1956 Sep 29;178(4535):694-5. doi: 10.1038/178694a0.
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[Immuno-electrophoretic study of normal human cerebrospinal fluid].[正常人脑脊液的免疫电泳研究]
Bull Soc Chim Biol (Paris). 1955;37(7-8):803-7.
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[Immunochemical study of siderophilin].[转铁蛋白的免疫化学研究]
Bull Soc Chim Biol (Paris). 1955;37(7-8):797-802.
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Isoelectric fractionation of proteins on polyacrylamide gels.蛋白质在聚丙烯酰胺凝胶上的等电分级分离
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