博来霉素与丝裂霉素C序贯给药对口腔区域鳞状细胞癌的影响。
Effects of sequential administration of bleomycin in combination with mitomycin C on squamous cell carcinoma of oral regions.
作者信息
Shingaki S, Kawasaki T, Nagamine T, Kanamaru T, Yokobayashi T, Nakajima T
出版信息
J Oral Surg. 1980 Dec;38(12):886-92.
PMID:6160232
Abstract
A sequential administration of bleomycin in combination with mitomycin C was evaluated clinically and histologically in ten patients with squamous cell carcinoma of the oral region. The therapy was effective against seven primary lesions and one metastatic lesion with an evident tendency to remission, but was completely ineffective against recurrent carcinomas. Myelosuppression seemed to be a more important toxic effect than the bleomycin-induced pneumonitis. The mechanism of action of the therapy and indications in clinical application are discussed.
摘要
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