博来霉素与丝裂霉素序贯联合治疗晚期宫颈癌——美国的经验：北加利福尼亚肿瘤学组的一项研究
Sequential combination of bleomycin and mitomycin in advanced cervical cancer--an American experience: a Northern California Oncology Group study.
作者信息
Greenberg B R, Hannigan J, Gerretson L, Turbow M M, Friedman M A, Hendrickson C A, Glassberg A, Carter S K
出版信息
Cancer Treat Rep. 1982 Jan;66(1):163-5.
Eighteen evaluable patients with advanced squamous cell carcinoma of the cervix were treated with a sequential combination of bleomycin and mitomycin. We observed no complete responses and only four partial responses (22% response frequency). The median duration of response was only 3.4 months, and the median survival time for the partial responders was 8.5 months versus 4.0 months for the nonresponders. Three cases of bleomycin pulmonary toxicity were reported, two of a severe grade. It appears that this combination is of limited effectiveness and is inferior to other combinations.
18例可评估的晚期宫颈鳞状细胞癌患者接受了博来霉素与丝裂霉素的序贯联合治疗。我们未观察到完全缓解，仅4例部分缓解（缓解频率为22%）。缓解的中位持续时间仅为3.4个月，部分缓解者的中位生存时间为8.5个月，而未缓解者为4.0个月。报告了3例博来霉素肺毒性病例，其中2例为重度。看来这种联合治疗效果有限，且不如其他联合治疗。
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