Mehra R, McMullen M, Furman S
Pacing Clin Electrophysiol. 1980 Sep;3(5):526-30. doi: 10.1111/j.1540-8159.1980.tb05271.x.
Following pacemaker electrode attachment, greater ventricular vulnerability to arrhythmias exists in an acutely ischemic ventricle with a unipolar anodal than cathodal stimulus falling on the T wave, due to the shorter refractory period exhibited by an anodal stimulus. In order to determine the relationship between anodal and cathodal refractory period at various times following endocardial electrode insertion, ventricular strength-interval curves were determined in nine dogs. With stable electrode position, serial measurements were made for a mean duration of 44 days. It was observed that during the first five days, the anodal refractory period was significantly shorter than cathodal, but within 15-20 days this relationship was reversed in all dogs. The longer anodal refractory period was observed up to the end of each study. These results suggest that due to shorter anodal refractory period, greater vulnerability to arrhythmias may occur with an anodal than cathodal stimulus in the initial 15-20 days following electrode insertion.
在起搏器电极附着后，急性缺血心室中，与阴极刺激落在T波上相比，阳极单极刺激落在T波上时心室对心律失常的易感性更高，这是因为阳极刺激的不应期较短。为了确定心内膜电极插入后不同时间阳极和阴极不应期之间的关系，在9只狗身上测定了心室强度-间期曲线。在电极位置稳定的情况下，进行了连续测量，平均持续时间为44天。观察到在最初的五天内，阳极不应期明显短于阴极不应期，但在15 - 20天内，所有狗的这种关系都发生了逆转。在每项研究结束时都观察到阳极不应期较长。这些结果表明，由于阳极不应期较短，在电极插入后的最初15 - 20天内，阳极刺激比阴极刺激可能导致更高的心律失常易感性。
