Rohr H P, Bartsch G
Urology. 1980 Dec;16(6):625-33. doi: 10.1016/0090-4295(80)90577-4.
Stereology is of great value for better understanding the pathomorphogenesis of benign prostatic hyperplasia (BPH) and the hormonally controlled mechanism of abnormal overgrowth of the prostate gland, especially the stromal component. In human BPH a fourfold absolute increase of the stromal part and a nearly double increase of the glandular part is indicated. The relative and absolute increase of the stromal part is surprisingly constant in spite of variation of human BPH. Stromal overgrowth can be viewed as a central feature of BPH implicating altered mesenchymal-epithelial relationship. At the ultrastructural level in man and dog the volume density of the secretory droplets and lysosomes of the glandular cells is reduced. Stereology data confirm furthermore the activation of the smooth muscle cells suggesting an induction of stromal growth possibly induced by estrogen and/or androgen and an important role in glandular-stromal interactions.
体视学对于更好地理解良性前列腺增生（BPH）的病理形态发生以及前列腺异常过度生长的激素控制机制，尤其是基质成分，具有重要价值。在人类BPH中，基质部分绝对增加了四倍，腺性部分几乎增加了一倍。尽管人类BPH存在差异，但基质部分的相对和绝对增加却惊人地恒定。基质过度生长可被视为BPH的一个核心特征，这意味着间充质 - 上皮关系发生了改变。在人和狗的超微结构水平上，腺细胞分泌滴和溶酶体的体积密度降低。体视学数据进一步证实了平滑肌细胞的激活，提示可能由雌激素和/或雄激素诱导基质生长，并在腺 - 基质相互作用中起重要作用。
