Cuypers J, Altenkirch H, Bunge S
Eur Neurol. 1979;18(5):345-7. doi: 10.1159/000115100.
Treatment with the histamine H2 receptor antagonist, cimetidine, alone and/or in combination with the histamine H1 receptor antagonist, chlorpyramine, in 13 patients showed that cimetidine alone was ineffective. 7 of 9 patients taking the combination of H1 and H2 receptor antagonists responded well to the treatment; in 1 patient, medication was ineffective and in 1 patient, success was doubtful. In 3 patients with chronic cluster headache, the effect faded after 4 weeks. The results are discussed.
对13名患者单独使用组胺H2受体拮抗剂西咪替丁和/或与组胺H1受体拮抗剂氯吡拉敏联合使用的治疗表明，单独使用西咪替丁无效。9名服用H1和H2受体拮抗剂组合的患者中有7名对治疗反应良好；1名患者用药无效，1名患者疗效存疑。3名慢性丛集性头痛患者的疗效在4周后消退。对结果进行了讨论。
