Takagi K, Itoh Y, Enomoto H, Koyamaishi Y, Maeda K, Kawai T
Clin Chim Acta. 1980 Dec 8;108(2):277-83. doi: 10.1016/0009-8981(80)90014-5.
The levels of serum alpha 1-microglobulin in 60 normal persons and in 191 patients suffering from a variety of benign and malignant disorders were determined by an enzyme immunoassay, and these values were compared with the levels of beta 2-microglobulin. A discrepancy between the serum levels of these proteins was found in hepatobiliary disorders; that is, an increased serum level of beta 2-microglobulin was observed in 73.9%, while in only 4.3% was there an elevation of alpha 1-microglobulin. In particular, alpha 1-microglobulin levels in patients with liver cirrhosis were well below the normal range, while beta 2-microglobulin levels were elevated. Elevated levels of both proteins were noted in patients with some impairments of renal function, particularly in chronic renal failure, and in immunological diseases. In 81 patients with neoplastic diseases, a high alpha 1-microglobulin value was found in only 15 patients (16.4%), while a high beta 2-microglobulin value in 62 patients (76.5%). The serum levels of both alpha 1-microglobulin and beta 2-microglobulin were especially high in plasma cell dyscrasia with Bence Jones protein, but other neoplastic diseases were mostly associated with beta 2-microglobulin elevation alone.
采用酶免疫分析法测定了60名正常人和191名患有各种良性和恶性疾病患者的血清α1 -微球蛋白水平，并将这些值与β2 -微球蛋白水平进行了比较。在肝胆疾病中发现了这些蛋白质血清水平之间的差异；也就是说，73.9%的患者观察到血清β2 -微球蛋白水平升高，而只有4.3%的患者α1 -微球蛋白升高。特别是，肝硬化患者的α1 -微球蛋白水平远低于正常范围，而β2 -微球蛋白水平升高。在一些肾功能受损的患者中，尤其是慢性肾衰竭患者和免疫性疾病患者中，两种蛋白质水平均升高。在81名肿瘤疾病患者中，仅15名患者（16.4%）的α1 -微球蛋白值较高，而62名患者（76.5%）的β2 -微球蛋白值较高。在伴有本-周蛋白的浆细胞发育异常中，α1 -微球蛋白和β2 -微球蛋白的血清水平特别高，但其他肿瘤疾病大多仅与β2 -微球蛋白升高有关。
