Parrish R W, Williams J D, Davies B H
Thorax. 1982 Dec;37(12):936-40. doi: 10.1136/thx.37.12.936.
Angiotensin-converting enzyme activity in sarcoidosis is regarded both as a diagnostic feature and as an index of disease activity. Increased activity of this enzyme is thought to parallel macrophage and epithelioid cell activity. Beta-2-microglobulin, a low-molecular-weight protein associated with the histocompatibility antigens, is thought to reflect activation of immunocompetent cells, particularly lymphocytes. In 132 patients with known sarcoidosis no close association was found to exist between the results of the two assays (r = 0.53). Angiotensin-converting enzyme activity was raised in 33% and beta 2-microglobulin concentrations in 63% of patients with sarcoidosis. When analysed prospectively, the results of the two assays showed no correlation in 29 patients over periods of up to 19 months. Stage, duration of disease, and corticosteroid treatment showed no significant effect on levels of either angiotensin-converting enzyme or beta 2-microglobulin. The disparity between indices of macrophage and lymphocyte activation requires further study in sarcoidosis.
结节病中的血管紧张素转换酶活性既被视为一种诊断特征，也被当作疾病活动的一个指标。这种酶活性的增加被认为与巨噬细胞和上皮样细胞的活性平行。β2-微球蛋白是一种与组织相容性抗原相关的低分子量蛋白质，被认为可反映免疫活性细胞尤其是淋巴细胞的激活情况。在132例已知患有结节病的患者中，这两种检测结果之间未发现密切关联（r = 0.53）。结节病患者中33%的血管紧张素转换酶活性升高，63%的患者β2-微球蛋白浓度升高。对29例患者进行长达19个月的前瞻性分析时，这两种检测结果无相关性。疾病分期、病程及皮质类固醇治疗对血管紧张素转换酶或β2-微球蛋白水平均无显著影响。结节病中巨噬细胞和淋巴细胞激活指标之间的差异需要进一步研究。
