Shuster J, Gold P, Poulik M D
Clin Chim Acta. 1976 Mar 15;67(3):307-13. doi: 10.1016/0009-8981(76)90339-9.
Serum beta2-microglobulin levels were measured, by radioimmunoassay, in patients suffering from a variety of benign and malignant clinical disorders. Elevated beta 2-microglobulin values were found in neoplastic and non-neoplastic disorders affecting a variety of organs. The most striking increases in beta 2-microglobulin are found in the plasma cell dyscrazias and several solid tumors, particularly those affecting the lung. Lymphoid neoplasms demonstrate a spectrum of changes of serum beta 2-microglobulin. At the one end of this spectrum were the plasma cell tumors, which show a high incidence of raised beta 2-microglobulin levels, while patients with Hodgkin's disease rarely show such increases in circulating beta 2-microglobulin.
通过放射免疫测定法，对患有各种良性和恶性临床疾病的患者血清β2-微球蛋白水平进行了测量。在影响多种器官的肿瘤性和非肿瘤性疾病中发现β2-微球蛋白值升高。β2-微球蛋白升高最为显著的情况见于浆细胞异常增殖症和几种实体瘤，尤其是那些影响肺部的实体瘤。淋巴系统肿瘤表现出血清β2-微球蛋白的一系列变化。在这个变化范围的一端是浆细胞瘤，其β2-微球蛋白水平升高的发生率很高，而霍奇金病患者循环中的β2-微球蛋白很少出现这种升高。
