文献检索，用中文搜 PubMed

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Haeusler G, Osterwalder R

Clin Sci (Lond). 1980 Dec;59 Suppl 6:295s-297s. doi: 10.1042/cs059295s.

Substance P, injected into a lateral brain ventricle of urethane-anaesthetized rats, caused dose-dependent increases in blood pressure and heart rate. 2. By contrast, exposure of the obex region of the medulla oblongata to pieces of filter paper soaked in substance P-containing solution resulted in falls of blood pressure and heart rate in both rats and cats. 3. A more precise application of substance P to the first synapse of the baroreceptor reflex by micro-injection into defined areas of the nucleus of the solitary tract also led to an activation of the baroreceptor reflex. 4. Capsaicin, which is known to release substance P from primary afferents, mimicked the sympatho-inhibitory and cardiovascular effects of substance P when applied locally to the nucleus of the solitary tract. 5. The results are compatible with a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflex.

向经乌拉坦麻醉的大鼠侧脑室注射P物质，可使血压和心率呈剂量依赖性升高。2. 相比之下，将浸有含P物质溶液的滤纸块置于延髓闩部，可导致大鼠和猫的血压和心率下降。3. 通过微量注射将P物质更精确地应用于孤束核特定区域的压力感受器反射的第一个突触，也会导致压力感受器反射激活。4. 已知辣椒素可从初级传入神经释放P物质，当局部应用于孤束核时，可模拟P物质的交感抑制和心血管效应。5. 这些结果与P物质在压力感受器反射的第一个突触处作为递质或神经调质的作用相一致。

Haeusler G, Osterwalder R

Clin Sci (Lond). 1980 Dec;59 Suppl 6:295s-297s. doi: 10.1042/cs059295s.

Substance P, injected into a lateral brain ventricle of urethane-anaesthetized rats, caused dose-dependent increases in blood pressure and heart rate. 2. By contrast, exposure of the obex region of the medulla oblongata to pieces of filter paper soaked in substance P-containing solution resulted in falls of blood pressure and heart rate in both rats and cats. 3. A more precise application of substance P to the first synapse of the baroreceptor reflex by micro-injection into defined areas of the nucleus of the solitary tract also led to an activation of the baroreceptor reflex. 4. Capsaicin, which is known to release substance P from primary afferents, mimicked the sympatho-inhibitory and cardiovascular effects of substance P when applied locally to the nucleus of the solitary tract. 5. The results are compatible with a transmitter or neuromodulatory role for substance P at the first synapse of the baroreceptor reflex.

向经乌拉坦麻醉的大鼠侧脑室注射P物质，可使血压和心率呈剂量依赖性升高。2. 相比之下，将浸有含P物质溶液的滤纸块置于延髓闩部，可导致大鼠和猫的血压和心率下降。3. 通过微量注射将P物质更精确地应用于孤束核特定区域的压力感受器反射的第一个突触，也会导致压力感受器反射激活。4. 已知辣椒素可从初级传入神经释放P物质，当局部应用于孤束核时，可模拟P物质的交感抑制和心血管效应。5. 这些结果与P物质在压力感受器反射的第一个突触处作为递质或神经调质的作用相一致。