Mayer N, Gamse R, Lembeck F
J Neurochem. 1980 Nov;35(5):1238-41. doi: 10.1111/j.1471-4159.1980.tb07881.x.
Newborn or adult rats were pretreated with 50 mg kg-1 capsaicin. At the age of 2 to 4 months, binding of 125I-labelled Tyr8-substance P to synaptic vesicles prepared from different regions of the nervous system was examined. In both groups, capsaicin pretreatment led to a significant decrease in the number of binding sites in dorsal roots and spinal cord without having an effect on affinity. This decrease parallels the depletion of the substance P content (Gamse et al., 1980) and can be explained by degeneration of primary sensory neurons in newborn treated rats and by depletion of vesicles in adult treated rats.
新生或成年大鼠用50mg/kg辣椒素进行预处理。在2至4个月龄时，检测了125I标记的酪氨酸8-P物质与从神经系统不同区域制备的突触小泡的结合情况。在两组中，辣椒素预处理均导致背根和脊髓中结合位点数量显著减少，而对亲和力无影响。这种减少与P物质含量的耗尽（Gamse等人，1980年）平行，并且可以用新生处理大鼠中初级感觉神经元的退化以及成年处理大鼠中突触小泡的耗尽来解释。
