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1
The heterogenization of tumour cells with tuberculin. I. The coupling of tuberculin to cell surfaces using con-A as ligand.肿瘤细胞与结核菌素的异质性。I. 以伴刀豆球蛋白A作为配体将结核菌素偶联至细胞表面。
Immunology. 1981 Feb;42(2):329-36.
2
The heterogenization of tumour cells with tuberculin. II. Studies of the antigenicity of tuberculin-heterogenized murine tumour cells in syngeneic BCG positive and BCG negative mice.肿瘤细胞与结核菌素的异质化。II. 结核菌素异质化的小鼠肿瘤细胞在同基因卡介苗阳性和阴性小鼠中的抗原性研究。
Immunology. 1981 Feb;42(2):337-48.
3
Studies in the enhancement of tumour immunity by coupling strong antigens to tumour cells ('heterogenization of tumours'). Helper T cell clones against PPD help other T cells mount anti-tumour responses to PPD-coupled tumour cells.通过将强抗原与肿瘤细胞偶联来增强肿瘤免疫的研究（“肿瘤异质化”）。针对结核菌素纯蛋白衍生物（PPD）的辅助性T细胞克隆可帮助其他T细胞对PPD偶联的肿瘤细胞产生抗肿瘤反应。
Immunology. 1984 Apr;51(4):755-63.
4
Induction of resistance to ascites tumor in mice with MFS-180 cells treated with glutaraldehyde, lipopolysaccharide, and concanavalin A.用戊二醛、脂多糖和伴刀豆球蛋白A处理的MFS - 180细胞诱导小鼠对腹水瘤的抗性。
Cancer Res. 1981 Jul;41(7):2922-4.
5
The killing of tumour cell targets coupled to tuberculin (PPD) by human and murine PPD-reactive T helper clones. I. PPD specificity of killing.人源和鼠源结核菌素（PPD）反应性辅助性T细胞克隆对与结核菌素（PPD）偶联的肿瘤细胞靶标的杀伤作用。I. 杀伤作用的PPD特异性。
Scand J Immunol. 1988 Mar;27(3):337-46. doi: 10.1111/j.1365-3083.1988.tb02355.x.
6
[Analysis of in vitro immune responses in humans using T cell clones and monoclonal antibodies].[利用T细胞克隆和单克隆抗体对人类体外免疫反应的分析]
Hokkaido Igaku Zasshi. 1984 May;59(3):346-55.
7
A 12-kDa protein of Mycobacterium tuberculosis protects mice against experimental autoimmune encephalomyelitis. Protection in the absence of shared T cell epitopes with encephalitogenic proteins.结核分枝杆菌的一种12千道尔顿蛋白可保护小鼠免受实验性自身免疫性脑脊髓炎的侵害。在与致脑炎性蛋白不存在共享T细胞表位的情况下提供保护。
J Immunol. 1995 Mar 15;154(6):2939-48.
8
In vitro lymphocyte stimulation in patients with lepromatous and borderline tuberculoid leprosy. The effect of dapsone treatment on the response to Mycobacterium leprae antigens, tuberculin purified protein derivative and non-mycobacterial stimulants.瘤型和界线类偏结核样型麻风患者的体外淋巴细胞刺激。氨苯砜治疗对麻风分枝杆菌抗原、结核菌素纯蛋白衍生物及非分枝杆菌刺激物反应的影响。
Int J Lepr Other Mycobact Dis. 1982 Dec;50(4):455-67.
9
Establishment of three PPD-reactive helper T cell clones with distinct functions in B cell activation.建立在B细胞活化中具有不同功能的三个PPD反应性辅助性T细胞克隆。
J Immunol. 1984 Aug;133(2):629-35.
10
[Immunological aspects of Mycobacterium avium complex infection].
Kekkaku. 1993 Jan;68(1):71-8.

引用本文的文献

1
Studies in the enhancement of tumour immunity by coupling strong antigens to tumour cells ('heterogenization of tumours'). Helper T cell clones against PPD help other T cells mount anti-tumour responses to PPD-coupled tumour cells.通过将强抗原与肿瘤细胞偶联来增强肿瘤免疫的研究（“肿瘤异质化”）。针对结核菌素纯蛋白衍生物（PPD）的辅助性T细胞克隆可帮助其他T细胞对PPD偶联的肿瘤细胞产生抗肿瘤反应。
Immunology. 1984 Apr;51(4):755-63.
2
A preliminary trial of a novel form of active immunotherapy in squamous cell carcinoma of the lung.一种新型主动免疫疗法在肺鳞状细胞癌中的初步试验。
Br J Cancer. 1985 Mar;51(3):415-7. doi: 10.1038/bjc.1985.56.
3
Immunoconjugates: applications in targeted drug delivery for cancer therapy.免疫偶联物：在癌症治疗的靶向药物递送中的应用。
Pharm Res. 1987 Jun;4(3):181-8. doi: 10.1023/a:1016443725167.
4
Purified protein derivative (PPD).纯化蛋白衍生物（PPD）。
Springer Semin Immunopathol. 1988;10(4):301-4. doi: 10.1007/BF02053842.

本文引用的文献

1
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
2
The heterogenization of tumour cells with tuberculin. II. Studies of the antigenicity of tuberculin-heterogenized murine tumour cells in syngeneic BCG positive and BCG negative mice.肿瘤细胞与结核菌素的异质化。II. 结核菌素异质化的小鼠肿瘤细胞在同基因卡介苗阳性和阴性小鼠中的抗原性研究。
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Glutaraldehyde--its purity and stability.戊二醛——其纯度与稳定性。
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4
Synergy during in vitro cytotoxic allograft responses. I. Evidence for cell interaction between thymocytes and peripheral T cells.体外细胞毒性同种异体移植反应中的协同作用。I. 胸腺细胞与外周T细胞之间细胞相互作用的证据。
J Exp Med. 1973 Dec 1;138(6):1379-97. doi: 10.1084/jem.138.6.1379.
5
Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse.Ly - A和Ly - B：小鼠淋巴细胞同种抗原的两个系统。
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6
Viral oncolysis: increased immunogenicity of host cell antigen associated with influenza virus.病毒溶瘤作用：与流感病毒相关的宿主细胞抗原免疫原性增强。
J Exp Med. 1967 Jul 1;126(1):93-108. doi: 10.1084/jem.126.1.93.
7
The requirement of more than one antigenic determinant for immunogenicity.免疫原性需要不止一个抗原决定簇。
J Exp Med. 1969 Jun 1;129(6):1131-43. doi: 10.1084/jem.129.6.1131.
8
Editorial: Immune activation of B cells: evidence for 'one nonspecific triggering signal' not delivered by the Ig receptors.社论：B细胞的免疫激活：Ig受体未传递“单一非特异性触发信号”的证据
Scand J Immunol. 1974;3(2):133-46.
9
Coupling PPD to tumour cells enhances their antigenicity in BCG-primed mice.将结核菌素纯蛋白衍生物（PPD）与肿瘤细胞偶联可增强其在卡介苗预致敏小鼠中的抗原性。
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10
The regulation of lymphocyte functions by the macrophage.巨噬细胞对淋巴细胞功能的调节
Immunol Rev. 1978;40:227-55. doi: 10.1111/j.1600-065x.1978.tb00408.x.

肿瘤细胞与结核菌素的异质性。I. 以伴刀豆球蛋白A作为配体将结核菌素偶联至细胞表面。

The heterogenization of tumour cells with tuberculin. I. The coupling of tuberculin to cell surfaces using con-A as ligand.

作者信息

Lachmann P J, Vyakarnam A, Sikora K

出版信息

Immunology. 1981 Feb;42(2):329-36.

PMID:6161888
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1458089/
Abstract

The introduction of an antigenic determinant strongly recognized by T cells on to a cell enhances the immune response to weak cellular antigens. Tuberculin (PPD) is a particularly suitable antigenic determinant for this purpose since it behaves in many ways as a 'T-cell hapten'. It has been found that direct chemical coupling of PPD to cell surfaces damages their antigenicity, but that this can be circumvented by coupling PPD to the lectin Concanavalin A and using this as the ligand for binding PPD to the cell. Techniques for preparing Con-A/PPD using little glutaraldehyde or SPDP as cross-linking agents are described.

摘要

将一种能被T细胞强烈识别的抗原决定簇引入细胞，可增强对弱细胞抗原的免疫反应。结核菌素（PPD）是用于此目的的一种特别合适的抗原决定簇，因为它在许多方面表现为一种“T细胞半抗原”。已发现将PPD直接化学偶联到细胞表面会损害其抗原性，但这可通过将PPD偶联到凝集素伴刀豆球蛋白A并将其用作使PPD与细胞结合的配体来规避。本文描述了使用少量戊二醛或SPDP作为交联剂制备伴刀豆球蛋白A/PPD的技术。