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小鼠肝脏和唾液腺的α-淀粉酶信使核糖核酸仅在5'非翻译序列上有所不同。

Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences.

作者信息

Hagenbüchle O, Tosi M, Schibler U, Bovey R, Wellauer P K, Young R A

出版信息

Nature. 1981 Feb 19;289(5799):643-6. doi: 10.1038/289643a0.

DOI:10.1038/289643a0
PMID:6162108
Abstract

The sequence of 1,773-nucleotide major and 1,806-nucleotide minor mouse liver alpha-amylase mRNAs differ only with respect to approximately 30 additional residues at the extreme 5' terminus of the minor species. Comparison of the liver alpha-amylase mRNAs with their salivary gland counterpart reveals that these mRNAs share identical coding and 3'-noncoding sequences, but contain distinct 5'-terminal residues. These data suggest that all three mRNAs might be transcribed from the same gene.

摘要

1773个核苷酸的主要小鼠肝脏α-淀粉酶mRNA序列与1806个核苷酸的次要小鼠肝脏α-淀粉酶mRNA序列仅在次要序列5'末端的大约30个额外残基方面有所不同。将肝脏α-淀粉酶mRNA与其唾液腺对应物进行比较发现,这些mRNA共享相同的编码和3'非编码序列,但含有不同的5'末端残基。这些数据表明,所有这三种mRNA可能都转录自同一个基因。

相似文献

1
Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5' non-translated sequences.小鼠肝脏和唾液腺的α-淀粉酶信使核糖核酸仅在5'非翻译序列上有所不同。
Nature. 1981 Feb 19;289(5799):643-6. doi: 10.1038/289643a0.
2
A single mouse alpha-amylase gene specifies two different tissue-specific mRNAs.单个小鼠α-淀粉酶基因可产生两种不同的组织特异性mRNA。
Cell. 1981 Feb;23(2):451-8. doi: 10.1016/0092-8674(81)90140-9.
3
Tissue-specific expression of mouse-alpha-amylase genes: nucleotide sequence of isoenzyme mRNAs from pancreas and salivary gland.小鼠α-淀粉酶基因的组织特异性表达:来自胰腺和唾液腺的同工酶mRNA的核苷酸序列。
Cell. 1980 Aug;21(1):179-87. doi: 10.1016/0092-8674(80)90125-7.
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Multiple polyadenylation sites in a mouse alpha-amylase gene.小鼠α-淀粉酶基因中的多个聚腺苷酸化位点。
Nucleic Acids Res. 1981 May 25;9(10):2313-23. doi: 10.1093/nar/9.10.2313.
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Tissue specific expression of mouse alpha-amylase genes.小鼠α-淀粉酶基因的组织特异性表达。
Adv Exp Med Biol. 1982;158:381-5. doi: 10.1007/978-1-4899-5292-9_40.
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The mouse alpha-amylase multigene family. Sequence organization of members expressed in the pancreas, salivary gland and liver.小鼠α-淀粉酶多基因家族。在胰腺、唾液腺和肝脏中表达的成员的序列组织。
J Mol Biol. 1982 Mar 5;155(3):247-66. doi: 10.1016/0022-2836(82)90004-3.
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Isolation and characterization of alpha-amylase messenger RNA from bank vole parotid glands. Evidence for two separate messenger RNAs coding for amylase and an amylase-related protein.从棕背䶄腮腺中分离和鉴定α-淀粉酶信使核糖核酸。编码淀粉酶和一种淀粉酶相关蛋白的两种不同信使核糖核酸的证据。
Eur J Biochem. 1981 Jun;117(1):81-6. doi: 10.1111/j.1432-1033.1981.tb06305.x.
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Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver.两种不同强度的启动子控制着小鼠腮腺和肝脏中α-淀粉酶基因Amy-1a的转录。
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Expression of mouse Amy-2a alpha-amylase genes is regulated by strong pancreas-specific promoters.小鼠Amy-2aα-淀粉酶基因的表达受强大的胰腺特异性启动子调控。
J Mol Biol. 1985 Sep 20;185(2):285-93. doi: 10.1016/0022-2836(85)90404-8.
10
Tissue-specific expression of alpha-amylase.α-淀粉酶的组织特异性表达
Nature. 1981 Apr 16;290(5807):541-2. doi: 10.1038/290541a0.

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