内源性抗坏血酸水平变化对主动致敏豚鼠肺组织碎片中组胺和过敏反应慢反应物质体外免疫释放的影响。
Effect of variation in endogenous levels of ascorbic acid on the in vitro immunological release of histamine and slow reacting substance of anaphylaxis from actively sensitized guinea-pig lung fragments.
作者信息
Hitchcock M
出版信息
Br J Pharmacol. 1980;71(2):539-43. doi: 10.1111/j.1476-5381.1980.tb10970.x.
Abstract
- The in vitro immunological release of histamine and slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments was greatly reduced when the animals were maintained on an ascorbic acid-deficient diet. Excessive dietary levels of ascorbic acid did not increase mediator release above normal levels. 2. Restoration of ascorbic acid in the diet of scorbutic guinea-pigs restored in vitro immunological histamine to normal levels. 3. Variation in dietary levels of ascorbic acid had no effect on lung histamine content. 4. The lung ascorbic acid content was proportional to the dietary intake. Approximately 60% of the total lung ascorbic acid was removed by the process of chopping and washing of the tissue. This relationship was independent of dietary intake. 5. The results indicate that the immunological release of mediators of inflammation from guinea-pig lung is dependent on adequate endogenous levels of ascorbic acid.
摘要
- 当动物维持在缺乏抗坏血酸的饮食时，主动致敏的豚鼠肺组织碎片中组胺和过敏反应慢反应物质（SRS - A）的体外免疫释放显著降低。饮食中过量的抗坏血酸不会使介质释放增加至正常水平以上。2. 在患坏血病的豚鼠饮食中恢复抗坏血酸可使体外免疫组胺恢复至正常水平。3. 饮食中抗坏血酸水平的变化对肺组胺含量无影响。4. 肺抗坏血酸含量与饮食摄入量成正比。组织切碎和冲洗过程会去除约60%的肺总抗坏血酸。这种关系与饮食摄入量无关。5. 结果表明，豚鼠肺炎症介质的免疫释放依赖于足够的内源性抗坏血酸水平。
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Effect of variation in endogenous levels of ascorbic acid on the in vitro immunological release of histamine and slow reacting substance of anaphylaxis from actively sensitized guinea-pig lung fragments.内源性抗坏血酸水平变化对主动致敏豚鼠肺组织碎片中组胺和过敏反应慢反应物质体外免疫释放的影响。
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