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1
Effect of variation in endogenous levels of ascorbic acid on the in vitro immunological release of histamine and slow reacting substance of anaphylaxis from actively sensitized guinea-pig lung fragments.内源性抗坏血酸水平变化对主动致敏豚鼠肺组织碎片中组胺和过敏反应慢反应物质体外免疫释放的影响。
Br J Pharmacol. 1980;71(2):539-43. doi: 10.1111/j.1476-5381.1980.tb10970.x.
2
Stimulation of the antigen-induced contraction of guinea-pig trachea and immunological release of histamine and SRS-A from sensitized guinea-pig lung by (2-isopropyl-3-indolyl)-3 pyridyl ketone (L8027) and indomethacin.（2-异丙基-3-吲哚基）-3-吡啶基酮（L8027）和吲哚美辛对豚鼠气管抗原诱导收缩的刺激作用以及对致敏豚鼠肺中组胺和慢反应物质-A的免疫释放作用。
Br J Pharmacol. 1980;71(1):65-73. doi: 10.1111/j.1476-5381.1980.tb10910.x.
3
Effect of butyl 3-(1H-tetrazol-5-Yl) oxanilate (MTB) on immunological or non-immunological histamine and SRS(-A) release from guinea-pig, monkey and human lung tissue.3-(1H-四氮唑-5-基)氧代苯甲酸丁酯（MTB）对豚鼠、猴和人肺组织中免疫性或非免疫性组胺及慢反应物质（SRS-A）释放的影响。
Jpn J Pharmacol. 1987 Aug;44(4):447-53. doi: 10.1254/jjp.44.447.
4
Non-immunological release of slow-reacting substance from guinea-pig lungs.豚鼠肺中慢反应物质的非免疫性释放。
Br J Pharmacol. 1979 Sep;67(1):67-72.
5
Effects of sodium cromoglycate analogues on the immunological release of slow reacting substance of anaphylaxis and histamine from human and guinea-pig lung in vitro.色甘酸钠类似物对人及豚鼠肺组织在体外免疫释放过敏反应慢反应物质和组胺的影响。
J Pharm Pharmacol. 1982 Jun;34(6):401-2. doi: 10.1111/j.2042-7158.1982.tb04741.x.
6
Smooth muscle contraction and release of histamine and slow-reacting substance of anaphylaxis in pulmonary tissues isolated from guinea pigs passively sensitized with IgG1 or IgE antibodies.用IgG1或IgE抗体被动致敏的豚鼠肺组织中，平滑肌收缩以及组胺和过敏反应慢反应物质的释放。
Am Rev Respir Dis. 1985 Feb;131(2):260-6. doi: 10.1164/arrd.1985.131.2.260.
7
Anaphylaxis in chopped guinea pig lung. II. Enhancement of the anaphylactic release of histamine and slow reacting substance by certain dibasic aliphatic acids and inhibition by monobasic fatty acids.豚鼠肺切碎物中的过敏反应。II. 某些二元脂肪酸对组胺和慢反应物质过敏释放的增强作用以及一元脂肪酸的抑制作用
J Exp Med. 1961 Mar 1;113(3):541-57. doi: 10.1084/jem.113.3.541.
8
Effect of inhibitors of prostaglandin synthesis and prostaglandins E2 and F2alpha on the immunologic release of mediators of inflammation from actively sensitized guinea-pig lung.前列腺素合成抑制剂以及前列腺素E2和F2α对主动致敏豚鼠肺脏炎症介质免疫释放的影响
J Pharmacol Exp Ther. 1978 Nov;207(2):630-40.
9
KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis.KC - 404：一种对过敏反应迟缓反应物质具有拮抗作用的潜在抗过敏剂。
Jpn J Pharmacol. 1983 Apr;33(2):267-78. doi: 10.1254/jjp.33.267.
10
[Release of histamine and slow reacting substance of anaphylaxis (SRS-A) from the sensitized guinea-pig lungs. 1. Experimental studies].[致敏豚鼠肺组织中组胺和过敏反应慢反应物质（SRS-A）的释放。1. 实验研究]
Nihon Kyobu Shikkan Gakkai Zasshi. 1976 Nov;14(11):645-9.

本文引用的文献

1
A method for the fluorometric assay of histamine in tissues.一种用于组织中组胺荧光测定的方法。
J Pharmacol Exp Ther. 1959 Nov;127:182-6.
2
THE INFLUENCE OF ASCORBIC ACID ON HISTAMINE METABOLISM IN GUINEA-PIGS.抗坏血酸对豚鼠组胺代谢的影响。
Br J Pharmacol Chemother. 1965 Jun;24(3):725-34. doi: 10.1111/j.1476-5381.1965.tb01628.x.
3
ANTI-ANAPHYLACTIC EFFECT OF VITAMIN C IN THE GUINEA-PIG.维生素C对豚鼠的抗过敏作用。
J Pharm Pharmacol. 1965 Jun;17:387. doi: 10.1111/j.2042-7158.1965.tb07690.x.
4
Role of arachidonic acid in the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) from sensitized guinea pig lung fragments: evidence that SRS-A is very similar or identical structurally to nonimmunologically induced forms of SRS.花生四烯酸在致敏豚鼠肺组织碎片合成过敏反应慢反应物质（SRS-A）中的作用：有证据表明SRS-A在结构上与非免疫诱导形式的SRS非常相似或相同。
J Immunol. 1980 Aug;125(2):946-55.
5
Characterization of prostaglandin synthetase in guinea pig lung. Isolation of a new prostaglandin derivative from arachidonic acid.豚鼠肺中前列腺素合成酶的特性。从花生四烯酸中分离出一种新的前列腺素衍生物。
Biochemistry. 1974 Jun 4;13(12):2598-604. doi: 10.1021/bi00709a020.
6
Inhibition of histamine-induced airway constriction by ascorbic acid.抗坏血酸对组胺诱导的气道收缩的抑制作用。
J Allergy Clin Immunol. 1973 Apr;51(4):218-26. doi: 10.1016/0091-6749(73)90141-3.
7
Ascorbic acid in rat lung.大鼠肺中的抗坏血酸。
Biochem Biophys Res Commun. 1974 Aug 19;59(4):1250-2. doi: 10.1016/0006-291x(74)90448-3.
8
The nature of the antagonism of bronchospasm in the guinea-pig by ascorbic acid.豚鼠体内抗坏血酸对支气管痉挛的拮抗作用的性质。
J Pharm Pharmacol. 1965 Sep;17(9):595-6. doi: 10.1111/j.2042-7158.1965.tb07729.x.
9
Effect of inhibitors of prostaglandin synthesis and prostaglandins E2 and F2alpha on the immunologic release of mediators of inflammation from actively sensitized guinea-pig lung.前列腺素合成抑制剂以及前列腺素E2和F2α对主动致敏豚鼠肺脏炎症介质免疫释放的影响
J Pharmacol Exp Ther. 1978 Nov;207(2):630-40.
10
The effect of vitamin C on antigen-induced bronchospasm.维生素C对抗原诱导的支气管痉挛的作用。
J Allergy Clin Immunol. 1979 Jan;63(1):61-4. doi: 10.1016/0091-6749(79)90163-5.

内源性抗坏血酸水平变化对主动致敏豚鼠肺组织碎片中组胺和过敏反应慢反应物质体外免疫释放的影响。

Effect of variation in endogenous levels of ascorbic acid on the in vitro immunological release of histamine and slow reacting substance of anaphylaxis from actively sensitized guinea-pig lung fragments.

作者信息

Hitchcock M

出版信息

Br J Pharmacol. 1980;71(2):539-43. doi: 10.1111/j.1476-5381.1980.tb10970.x.

DOI:10.1111/j.1476-5381.1980.tb10970.x
PMID:6162499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044460/
Abstract
  1. The in vitro immunological release of histamine and slow reacting substance of anaphylaxis (SRS-A) from actively sensitized guinea-pig lung fragments was greatly reduced when the animals were maintained on an ascorbic acid-deficient diet. Excessive dietary levels of ascorbic acid did not increase mediator release above normal levels. 2. Restoration of ascorbic acid in the diet of scorbutic guinea-pigs restored in vitro immunological histamine to normal levels. 3. Variation in dietary levels of ascorbic acid had no effect on lung histamine content. 4. The lung ascorbic acid content was proportional to the dietary intake. Approximately 60% of the total lung ascorbic acid was removed by the process of chopping and washing of the tissue. This relationship was independent of dietary intake. 5. The results indicate that the immunological release of mediators of inflammation from guinea-pig lung is dependent on adequate endogenous levels of ascorbic acid.
摘要
  1. 当动物维持在缺乏抗坏血酸的饮食时，主动致敏的豚鼠肺组织碎片中组胺和过敏反应慢反应物质（SRS - A）的体外免疫释放显著降低。饮食中过量的抗坏血酸不会使介质释放增加至正常水平以上。2. 在患坏血病的豚鼠饮食中恢复抗坏血酸可使体外免疫组胺恢复至正常水平。3. 饮食中抗坏血酸水平的变化对肺组胺含量无影响。4. 肺抗坏血酸含量与饮食摄入量成正比。组织切碎和冲洗过程会去除约60%的肺总抗坏血酸。这种关系与饮食摄入量无关。5. 结果表明，豚鼠肺炎症介质的免疫释放依赖于足够的内源性抗坏血酸水平。