Kordansky D W, Rosenthal R R, Norman P S
J Allergy Clin Immunol. 1979 Jan;63(1):61-4. doi: 10.1016/0091-6749(79)90163-5.
The effect of vitamin C pretreatment in preventing ragweed-induced bronchospasm was evaluated in 6 ragweed-sensitive asthmatics studied in a double-blind randomized fashion. The patients received either lactose capsules or 500 mg of ascorbic acid and were studied out of season. Antigen dose-response curves were determined prior to the administration of lactose or ascorbic acid in each individual subject and subsequently after administration of ascorbic acid or lactose. Bothe PD20FEV1 (provocation dose necessary for a 20% reduction in forced expiratory volume in 1 second) and PD35SGaw (provocation dose necessary for a 35% reduction in specific airways conductance) were determined. In none of the six patients was there a change in baseline FEV 1 (p greater than 0.70) nor the overall average baseline specific airways conductance (rho greater than 0.90). Additionally, no statistically significant difference (p greater than 0.60) was noted between log PD35SGaw vitamin C day and lactose day. Likewise, no statistically significant difference (p greater than 0.60) was evident when comparing log PD20FEV1 lactose and ascorbic acid days. Vitamin C (500 MG) HAS NO PROTECTIVE EFFECT AGAINST RAGWEED ANTIGEN-INDUCED BRONCHOSPASM.
采用双盲随机方式，对6例豚草敏感型哮喘患者进行研究，评估维生素C预处理对预防豚草诱发支气管痉挛的效果。患者分别服用乳糖胶囊或500毫克抗坏血酸，并在非发病季节进行研究。在每位受试者服用乳糖或抗坏血酸之前以及之后，分别测定抗原剂量-反应曲线。同时测定PD20FEV1（使一秒用力呼气量降低20%所需的激发剂量）和PD35SGaw（使比气道传导率降低35%所需的激发剂量）。6例患者的基线FEV1均无变化（p>0.70），总体平均基线比气道传导率也无变化（rho>0.90）。此外，维生素C日与乳糖日的log PD35SGaw之间无统计学显著差异（p>0.60）。同样，比较乳糖日和抗坏血酸日的log PD20FEV1时，也无统计学显著差异（p>0.60）。维生素C（500毫克）对豚草抗原诱发的支气管痉挛无保护作用。
