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核糖核酸聚合酶抑制剂对短短芽孢杆菌中脱氧核糖核酸复制的抑制作用。

Inhibition of deoxyribonucleic acid replication in Bacillus brevis by ribonucleic acid polymerase inhibitors.

作者信息

Bhattacharya S, Sarkar N

出版信息

J Bacteriol. 1981 Mar;145(3):1442-4. doi: 10.1128/jb.145.3.1442-1444.1981.

DOI:10.1128/jb.145.3.1442-1444.1981
PMID:6162839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC217154/
Abstract

The incorporation of [3H]thymidine into deoxyribonucleic acid by exponentially growing cells of Bacillus brevis was inhibited by streptolydigin and rifampin in the same concentration range in which these drugs inhibit ribonucleic acid synthesis. Complete inhibition occurred within one-third generation time after drug addition, suggesting an effect on deoxyribonucleic acid chain elongation.

摘要

短短芽孢杆菌指数生长期的细胞将[3H]胸苷掺入脱氧核糖核酸的过程，受到链霉溶菌素和利福平的抑制，抑制浓度范围与这些药物抑制核糖核酸合成的浓度范围相同。添加药物后在三分之一代时内即发生完全抑制，这表明对脱氧核糖核酸链的延伸有影响。

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本文引用的文献

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Discontinuous DNA replication.不连续DNA复制
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Initiation of deoxyribonucleic acid replication in a temperature-sensitive mutant of B. subtilis: evidence for a transcriptional step.枯草芽孢杆菌温度敏感突变体中脱氧核糖核酸复制的起始：转录步骤的证据。
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Involvement of RNA polymerase in the synthesis of DNA by growing and toluene-treated cells of Bacillus brevis.RNA聚合酶参与短短芽孢杆菌生长细胞和甲苯处理细胞的DNA合成。
Biochem Biophys Res Commun. 1975 Jan 20;62(2):212-9. doi: 10.1016/s0006-291x(75)80125-2.