枯草芽孢杆菌产孢特性改变的耐利福平及耐链霉溶菌素突变体的分离与鉴定
Isolation and characterization of rifampin-resistant and streptolydigin-resistant mutants of Bacillus subtilis with altered sporulation properties.
作者信息
Sonenshein A L, Cami B, Brevet J, Cote R
出版信息
J Bacteriol. 1974 Oct;120(1):253-65. doi: 10.1128/jb.120.1.253-265.1974.
Abstract
Mutants of Bacillus subtilis with altered deoxyribonucleic-dependent ribonucleic acid polymerase activity have been isolated and characterized. These mutants, selected as strains resistant to rifampin or streptolydigin, demonstrate drug-resistant in vitro ribonucleic acid synthesis. Sporeforming ability and support of phage infection are altered in many of the mutants. Mutations to rifampin and streptolydigin resistance have been located on the B. subtilis chromosome and ordered relative to the markers cysA14 and str.
摘要
已分离并鉴定出具有改变的依赖脱氧核糖核酸的核糖核酸聚合酶活性的枯草芽孢杆菌突变体。这些作为对利福平或链霉溶菌素耐药的菌株被挑选出来的突变体，在体外表现出耐药性核糖核酸合成。许多突变体的芽孢形成能力和噬菌体感染支持能力发生了改变。对利福平和链霉溶菌素耐药的突变已定位在枯草芽孢杆菌染色体上，并相对于标记cysA14和str进行了排序。
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