Pereira A T
J Clin Microbiol. 1981 Feb;13(2):245-7. doi: 10.1128/jcm.13.2.245-247.1981.
The plating of successive Staphylococcus aureus subcultures of daily transfers proved that discontinuous variation resembling a genetic mutation and selective outgrowth of the variant are responsible for antigen variation. Every subculture of S. aureus, when repeatedly transferred, contained a mixture of cells with original antigen 17 (or 13) and final antigen 1 (or 3) that are relevant for research, serological diagnosis, and epidemiological study of staphylococcal diseases.
每日传代的金黄色葡萄球菌连续传代培养证明，类似于基因突变的间断性变异以及变异体的选择性生长是抗原变异的原因。金黄色葡萄球菌的每一次传代培养，在反复传代时，都含有与葡萄球菌疾病的研究、血清学诊断及流行病学研究相关的具有原始抗原17（或13）和最终抗原1（或3）的细胞混合物。
