干扰素：在皮肤病治疗中的现状。

Interferon: status in treatment of skin disease.

作者信息

Yancey K B, Smith J G

出版信息

J Am Acad Dermatol. 1980 Dec;3(6):585-95. doi: 10.1016/s0190-9622(80)80071-5.

Abstract

Interferons, glycoproteins originally investigated as antiviral agents, are now known to be active as anticancer agents, immune system modulators, and growth control regulators. For these reasons, interferons have definite and documented relevance to dermatologists. In regard to viral diseases, therapeutic trials in humans have shown promising results in herpes simplex infections, vaccinia, laryngeal papillomas, and condyloma acuminatum, as well as in rabies and hepatitis B. Pilot studies with interferon treatment of melanoma have been so promising that the American Cancer Society has selected this area to receive additional research support. Also, the antiproliferative effects of interferons have potential application to proliferative diseases such as psoriasis.

摘要

干扰素是最初作为抗病毒剂进行研究的糖蛋白，现在已知它作为抗癌剂、免疫系统调节剂和生长控制调节剂具有活性。由于这些原因，干扰素与皮肤科医生有着明确且有文献记载的相关性。在病毒性疾病方面，人体治疗试验已在单纯疱疹感染、牛痘、喉乳头状瘤和尖锐湿疣以及狂犬病和乙型肝炎中显示出有希望的结果。用干扰素治疗黑色素瘤的初步研究非常有前景，以至于美国癌症协会已选择该领域接受额外的研究支持。此外，干扰素的抗增殖作用在银屑病等增殖性疾病中具有潜在应用价值。