Stadler R, Mayer-da-Silva A, Bratzke B, Garbe C, Orfanos C
Department of Dermatology, University Medical Center Steglitz, Freie Universität Berlin, F.R. Germany.
J Am Acad Dermatol. 1989 Apr;20(4):650-6. doi: 10.1016/s0190-9622(89)70078-5.
Interferons are a large family of proteins and glycoproteins, naturally occurring or artificially produced by recombinant biotechnology. Their antiviral, antiproliferative, antitumoral, and immunomodulatory activities are induced by alterations in cell metabolism after binding to specific membrane receptors. Interferons have been used for the treatment of viral papillomas (e.g., verruca vulgaris and condyloma acuminatum), human immunodeficiency virus (HIV)-associated Kaposi's sarcoma and cutaneous tumors (e.g., melanoma, cutaneous T cell lymphoma, and basal cell carcinoma), and inflammatory dermatoses (e.g., Behçet's syndrome and psoriatic arthropathy). Clinical trials have been performed worldwide with various regimens and have not always led to conclusive results. In our experience long-term therapy with high doses of subcutaneously injected, recombinant interferon-alpha-2a in patients with HIV-associated Kaposi's sarcoma induces a remission or stabilization of the disease. In malignant melanoma a low response rate is obtained in metastatic disease with the use of interferon as a single therapeutic agent. Combined with other antitumor agents, however, interferon seems to be a useful drug. Excellent control of Behçet's disease has been obtained, and the treatment of condylomata acuminata has been effective.
干扰素是一大类蛋白质和糖蛋白，可天然存在或通过重组生物技术人工生产。它们的抗病毒、抗增殖、抗肿瘤和免疫调节活性是在与特定膜受体结合后，由细胞代谢改变所诱导产生的。干扰素已被用于治疗病毒性乳头瘤（如寻常疣和尖锐湿疣）、人类免疫缺陷病毒（HIV）相关的卡波西肉瘤和皮肤肿瘤（如黑色素瘤、皮肤T细胞淋巴瘤和基底细胞癌）以及炎症性皮肤病（如白塞病和银屑病关节炎）。世界各地已采用各种治疗方案进行了临床试验，但并非总能得出确凿的结果。根据我们的经验，对HIV相关的卡波西肉瘤患者采用高剂量皮下注射重组干扰素α-2a进行长期治疗可使疾病缓解或稳定。在恶性黑色素瘤中，使用干扰素作为单一治疗药物时，转移性疾病的缓解率较低。然而，与其他抗肿瘤药物联合使用时，干扰素似乎是一种有用的药物。白塞病已得到很好的控制，尖锐湿疣的治疗也很有效。
