Day E D, Varitek V A, Paterson P Y
J Neurol Sci. 1981 Jan;49(1):1-17. doi: 10.1016/0022-510x(81)90183-0.
MBP-SF, previously described as an endogenous myelin basic protein-serum factor in Lewis rats with a suggested function as a neuroautotolerogen, appears not to be a single factor but a heterogeneous collection of serum factors (MBP-SFs), most probably small fragments of MBP, each cross-reactive with a different region of the multideterminant parent molecule. The heterogeneity of the MBP-SFs in any serum sample is defined and limited by the spectrum of binding affinities of the antibody populations represented in a given reagent anti-MBP antiserum. Some samples of normal Lewis rat serum have been found to contain high affinity MBP-SFs which coexist with low affinity anti-MBP antibodies whereas other sera have shown the reversed pattern, viz. low affinity MBP-SFs and high affinity antibodies. Additional sera have been found to contain MBP-SFs of several different affinities. In time-course studies of rats sensitized to neuroantigen-adjuvant a variety of MBP-SFs and anti-MBP antibodies of different affinities may be observed in sequentially collected sera from a given animal. In no animal has any serum sample been found to contain the full spectrum of MBP-SFs. Although some MBP-SFs have been found to increase temporarily during the 2nd week after neuroantigen/CFA sensitization, all MBP-SFs tend to disappear in the 2nd week and to be replaced by anti-MBP antibodies of differing affinities 3-4 weeks following sensitization.
MBP-SF，先前被描述为Lewis大鼠体内的一种内源性髓鞘碱性蛋白-血清因子，被认为具有神经自身耐受原的功能，它似乎不是单一因子，而是血清因子（MBP-SFs）的异质集合，很可能是MBP的小片段，每个片段与多决定簇亲本分子的不同区域发生交叉反应。任何血清样本中MBP-SFs的异质性由给定试剂抗MBP抗血清中所代表的抗体群体的结合亲和力谱来定义和限制。已发现一些正常Lewis大鼠血清样本含有高亲和力的MBP-SFs，它们与低亲和力的抗MBP抗体共存，而其他血清则呈现相反的模式，即低亲和力的MBP-SFs和高亲和力的抗体。还发现其他血清含有几种不同亲和力的MBP-SFs。在对神经抗原-佐剂致敏大鼠的时间进程研究中，从给定动物顺序收集的血清中可能会观察到各种不同亲和力的MBP-SFs和抗MBP抗体。在任何动物中，均未发现任何血清样本含有完整谱的MBP-SFs。虽然已发现一些MBP-SFs在神经抗原/CFA致敏后的第2周会暂时增加，但所有MBP-SFs在第2周趋于消失，并在致敏后3-4周被不同亲和力的抗MBP抗体所取代。
