髓磷脂碱性蛋白血清因子。一种影响Lewis大鼠实验性过敏性脑脊髓炎发展的内源性神经抗原。
Myelin basic protein serum factor. An endogenous neuroantigen influencing development of experimental allergic encephalomyelitis in Lewis rats.
作者信息
Fujinami R S, Paterson P Y, Day E D, Varitek V A
出版信息
J Exp Med. 1978 Dec 1;148(6):1716-21. doi: 10.1084/jem.148.6.1716.
Abstract
Age-related concentrations of myelin basic protein serum factor (MBP-SF), an endogenous neuroantigen detected and quantitated by inhibition of binding of rat myelin basic protein (RMBP) antibody with 125I-RMBP reagent antigen and immunochemically indistinguishable from native RMBP in this respect, reach peak levels as high as 21 ng/microliter among 2-3-wk-old normal suckling Lewis rats. Levels then progressively decline to low, usually undetectable levels of less than or equal to 0.6 ng/microliter MBP-equivalents in adult animals by 7 wk of age. MBP-SF levels are inversely related to the age-related increasing capacity of maturing Lewis rats to develop experimental allergic encephalomyelitis (EAE) after sensitization to MBP of syngeneic, but not xenogeneic, origin. MBP-SF appears to be an endogenous neuroimmunoregulatory product of potential importance for immunologic tolerance to autologous RMBP in Lewis rats.
摘要
髓鞘碱性蛋白血清因子（MBP - SF）是一种内源性神经抗原，通过抑制大鼠髓鞘碱性蛋白（RMBP）抗体与¹²⁵I - RMBP试剂抗原的结合来检测和定量，在这方面与天然RMBP在免疫化学上难以区分。在2至3周龄的正常哺乳Lewis大鼠中，与年龄相关的MBP - SF浓度达到峰值水平，高达21纳克/微升。到7周龄时，其水平随后逐渐下降至成年动物中低水平，通常低于或等于0.6纳克/微升MBP当量，通常无法检测到。MBP - SF水平与成熟Lewis大鼠在对同基因而非异种来源的MBP致敏后发生实验性变应性脑脊髓炎（EAE）的年龄相关增加能力呈负相关。MBP - SF似乎是一种内源性神经免疫调节产物，对Lewis大鼠对自身RMBP的免疫耐受具有潜在重要性。
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