Variations in the numbers and dimensions of tissue channels after injury.

The dimensions and numbers of tissue channels were estimated, using transmission electron microscopy after filling them with ferri-ferrocyanide precipitate, in the subcutaneous tissue of mice. They were studied in the normal condition, and at varying times after a simple incised wound. After this injury they increased very greatly indeed in numbers and dimensions, being maximal at 1 week. Six months elapsed before they returned to normal. The hydraulic conductivity was calculated. It increased by 10(5) times at the maximum, when clinical oedema was present.