Svennevig J L
Acta Pathol Microbiol Scand A. 1980 Nov;88(6):387-95. doi: 10.1111/j.1699-0463.1980.tb02511.x.
Inflammatory cells (the term is considered to include lymphocytes, plasma cells, macrophages, mast cells and PMN) were identified and quantitated in sections from human carcinomas. Two types of cellular infiltrates are described. In the stroma surrounding the cancer tissue (peritumoural) and, to a lesser degree, also within the malignant tissue (intratumoural), lymphocytes, plasma cells, macrophages and mast cells dominated, whilst numerous polymorph nucleated cells (PMN) and aggregates of macrophages characterized central tumour necroses. The demonstration of both T-lymphocytes and macrophages in and around the cancer tissue supports the view that a local immune reaction is initiated by the tumour, and the consistent finding of IgG, IgA and IgM plasma cells at the borders of the carcinomas, indicates that plasma cells are also part of an immune response at the tumour site. This view is further supported by the demonstration of an increased proportion of IgG containing plasma cells in the stroma of colon tumours, compared with normal mucosa.
在人类癌组织切片中识别并定量炎性细胞（该术语被认为包括淋巴细胞、浆细胞、巨噬细胞、肥大细胞和多形核白细胞）。描述了两种类型的细胞浸润。在癌组织周围的基质（肿瘤周围）以及在较小程度上在恶性组织内（肿瘤内），淋巴细胞、浆细胞、巨噬细胞和肥大细胞占主导，而大量多形核细胞（PMN）和巨噬细胞聚集物是中央肿瘤坏死的特征。癌组织内和周围T淋巴细胞和巨噬细胞的存在支持了肿瘤引发局部免疫反应的观点，并且在癌组织边界持续发现IgG、IgA和IgM浆细胞，表明浆细胞也是肿瘤部位免疫反应的一部分。与正常黏膜相比，结肠肿瘤基质中含IgG浆细胞比例增加的证据进一步支持了这一观点。
