Svennevig J L, Holter J
Acta Pathol Microbiol Scand A. 1981 Mar;89(2):147-55. doi: 10.1111/j.1699-0463.1981.tb00201.x.
Non-malignant inflammatory cells were studied in tissue sections and cell suspensions from 21 human lung carcinomas. The different cell types were identified and quantified by means of histochemical and immunohistochemical methods. All tumours were surrounded and to a lesser degree also infiltrated by lymphocytes, macrophages, plasma cells containing IgG, IgA, or IgM, and a small number of mast cells. No evident signs of cell necrosis were present in association with these mononuclear cell infiltrates. Central tumour necroses were dominated by large numbers of neutrophils and macrophages, a reaction considered to be secondary to ischemic necroses in rapidly expanding tumours. The weakest mononuclear cell infiltrates were found in tumours with extensive necrotic areas. Of the tumour lymphocytes 3-67% (mean 37%) were T-lymphocytes, 4-32% (mean 19%) were B-lymphocytes. The relation between these markers did not always correlate with the findings in peripheral blood: low percentages of T-lymphocytes were found in some tumours even when the percentage of T-lymphocytes in peripheral blood was within the normal range. The demonstration of both T-lymphocytes and macrophages in and around the tumour tissue may reflect a local immune response against the neoplastic cells, while the presence of plasma cells in all tumours supports the theory that the tumour also induces a local production of immunoglobulin which may interfere with the cellular immunity.
对21例人类肺癌的组织切片和细胞悬液中的非恶性炎症细胞进行了研究。通过组织化学和免疫组织化学方法对不同细胞类型进行鉴定和定量。所有肿瘤均被淋巴细胞、巨噬细胞、含有IgG、IgA或IgM的浆细胞以及少量肥大细胞包围，且在较小程度上也有浸润。与这些单核细胞浸润相关未见明显细胞坏死迹象。中央肿瘤坏死区以大量中性粒细胞和巨噬细胞为主，这种反应被认为是快速生长肿瘤中缺血性坏死的继发表现。在有广泛坏死区域的肿瘤中发现单核细胞浸润最弱。肿瘤淋巴细胞中3% - 67%（平均37%）为T淋巴细胞，4% - 32%（平均19%）为B淋巴细胞。这些标志物之间的关系并不总是与外周血中的发现相关：即使外周血中T淋巴细胞百分比在正常范围内，某些肿瘤中T淋巴细胞百分比也较低。肿瘤组织内及周围T淋巴细胞和巨噬细胞的存在可能反映了针对肿瘤细胞的局部免疫反应，而所有肿瘤中浆细胞的存在支持了肿瘤也诱导局部免疫球蛋白产生这一理论，后者可能干扰细胞免疫。
