Petersson B A, Svedinger I, Bohlinder K
Agents Actions. 1980 Nov;10(5):403-10. doi: 10.1007/BF01968037.
Pretreatment of human leukocytes with the new xanthine compound, 3,7-dihydro-1,8-dimethyl-3-phenyl-1H-purine-2,6-dione (D 4026), induced a dose-dependent and statistically significant inhibition of immunoglobulin E-mediated histamine release in the concentration interval 0.1-1000 microM. Histamine release elicited with suboptimum amounts of the triggering agent (anti-IgE or antigen) was inhibited to a greater extent than a release initiated with optimum amounts. At a concentration of 10 microM, D 4026 had at least the same inhibitory effect as 100 microM theophylline. When leukocytes were incubated simultaneously with D 4026 and a histamine H-2 receptor-stimulating drug (histamine or clonidine), the two drugs combined induced an inhibition significantly greater than the sum of their individual inhibitory effects. Only pure additive inhibitory effects were, however, obtained during simultaneous treatment of leukocytes with theophylline and histamine.
用新型黄嘌呤化合物3,7-二氢-1,8-二甲基-3-苯基-1H-嘌呤-2,6-二酮（D 4026）对人白细胞进行预处理，在0.1 - 1000微摩尔浓度范围内，可诱导免疫球蛋白E介导的组胺释放呈剂量依赖性且具有统计学意义的抑制作用。次最佳量触发剂（抗IgE或抗原）引发的组胺释放比最佳量引发的释放受到更大程度的抑制。在10微摩尔浓度下，D 4026的抑制作用至少与100微摩尔茶碱相同。当白细胞与D 4026和组胺H - 2受体刺激药物（组胺或可乐定）同时孵育时，两种药物联合诱导的抑制作用明显大于它们各自抑制作用的总和。然而，在用茶碱和组胺同时处理白细胞的过程中，仅获得了纯粹的相加抑制作用。
