茶碱对哮喘患儿白细胞和全血中抗IgE诱导释放的体外影响。
In vitro influence of theophylline on anti-IgE-induced release from leucocytes and whole blood in asthmatic children.
作者信息
Scheinmann P, Burtin C, Paupe H, Lebel B, Fermanian J
出版信息
Agents Actions. 1981 Apr;11(1-2):109-10. doi: 10.1007/BF01991474.
Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood. In th first group (21 children), histamine release was obtained both from whole blood and washed leucocytes and was inhibited by 10(-4) M theophylline. In the second group (5 children), histamine release required the presence of plasma and was not inhibited by 10(-4) M theophylline. Theophylline treatment was efficacious only in children of the first group.
关于茶碱对全血中抗IgE诱导的组胺释放的影响，发现了两组哮喘儿童。在第一组（21名儿童）中，全血和洗涤后的白细胞均可释放组胺，且10⁻⁴M的茶碱可抑制组胺释放。在第二组（5名儿童）中，组胺释放需要血浆存在，且10⁻⁴M的茶碱不能抑制组胺释放。茶碱治疗仅对第一组儿童有效。
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