正常小鼠和自身免疫小鼠中抗体反应的干扰素免疫调节由抑制性T细胞亚群介导。
Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell subsets.
作者信息
Attallah A M, Urritia-Shaw A, Khalit R Y, Steinberg A D, Ahmed A
出版信息
Int Arch Allergy Appl Immunol. 1981;64(3):353-8. doi: 10.1159/000232714.
PMID:6163737
Abstract
The mechanism through which interferon exerts immunoregulatory influence on antibody production in autoimmune NZB mice and normal Balb/C mice was studied. Interferon suppressed T cell-dependent anti-SRBC response in normal mice indirectly by activating suppressor T cells. The suppressor cell activity by interferon is mediated by Ly123+ cells presumably acting as feedback regulators for the suppression.
摘要
研究了干扰素对自身免疫性NZB小鼠和正常Balb/C小鼠抗体产生发挥免疫调节作用的机制。干扰素通过激活抑制性T细胞间接抑制正常小鼠中T细胞依赖性抗SRBC反应。干扰素的抑制细胞活性由Ly123+细胞介导，这些细胞可能作为抑制的反馈调节因子发挥作用。
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