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正常小鼠和自身免疫小鼠中抗体反应的干扰素免疫调节由抑制性T细胞亚群介导。

Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell subsets.

作者信息

Attallah A M, Urritia-Shaw A, Khalit R Y, Steinberg A D, Ahmed A

出版信息

Int Arch Allergy Appl Immunol. 1981;64(3):353-8. doi: 10.1159/000232714.

DOI:10.1159/000232714
PMID:6163737
Abstract

The mechanism through which interferon exerts immunoregulatory influence on antibody production in autoimmune NZB mice and normal Balb/C mice was studied. Interferon suppressed T cell-dependent anti-SRBC response in normal mice indirectly by activating suppressor T cells. The suppressor cell activity by interferon is mediated by Ly123+ cells presumably acting as feedback regulators for the suppression.

摘要

研究了干扰素对自身免疫性NZB小鼠和正常Balb/C小鼠抗体产生发挥免疫调节作用的机制。干扰素通过激活抑制性T细胞间接抑制正常小鼠中T细胞依赖性抗SRBC反应。干扰素的抑制细胞活性由Ly123+细胞介导，这些细胞可能作为抑制的反馈调节因子发挥作用。

相似文献

1
Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell subsets.正常小鼠和自身免疫小鼠中抗体反应的干扰素免疫调节由抑制性T细胞亚群介导。
Int Arch Allergy Appl Immunol. 1981;64(3):353-8. doi: 10.1159/000232714.
2
Thymic function in NZB mice. III. Impairment of the activity of specific suppressor cells involved in the regulation of antibody production against sheep red blood cells.NZB小鼠的胸腺功能。III. 参与调节抗绵羊红细胞抗体产生的特异性抑制细胞活性受损。
Clin Exp Immunol. 1980 Oct;42(1):1-9.
3
Suppressor T-cell activity in MRL/Mp-lpr/lpr mice: differential effects on primary and memory antibody responses of MRL/Mp-lpr/lpr and MRL/Mp-+/+ spleen cells to thymus dependent and thymus independent antigens in vitro.MRL/Mp-lpr/lpr小鼠中抑制性T细胞活性：体外对MRL/Mp-lpr/lpr和MRL/Mp-+/+脾细胞针对胸腺依赖性和胸腺非依赖性抗原的初次和记忆抗体反应的不同影响。
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4
Suppressor T cells and self-tolerance. Active suppression required for normal regulation of anti-erythrocyte autoantibody responses in spleen cells from nonautoimmune mice.抑制性T细胞与自身耐受性。非自身免疫小鼠脾细胞中抗红细胞自身抗体反应的正常调节需要活性抑制作用。
J Immunol. 1988 Jun 1;140(11):3779-85.
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Specific antigen-binding and antibody-secreting lymphocytes associated with the erythrocyte autoantibody responses of NZB and genetically unrelated mice.与新西兰黑鼠（NZB）及遗传不相关小鼠的红细胞自身抗体反应相关的特异性抗原结合及抗体分泌淋巴细胞。
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Differences between normal and autoimmune T cell responses to autologous erythrocytes and haemoglobin: impairment of haptoglobin-mediated inhibition in NZB spleen cells.正常和自身免疫性T细胞对自体红细胞和血红蛋白反应的差异：NZB脾细胞中触珠蛋白介导的抑制作用受损。
J Autoimmun. 1996 Aug;9(4):453-62. doi: 10.1006/jaut.1996.0062.
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Regulation of an in vitro anti-DNA antibody response by thymocytes and T cells from NZB/W and normal mice.NZB/W 小鼠和正常小鼠的胸腺细胞及 T 细胞对体外抗 DNA 抗体反应的调节
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Difference in thymus dependency between effector and suppressor T cells for delayed footpad reaction to sheep erythrocytes in mice.小鼠对绵羊红细胞迟发型足垫反应中效应性T细胞和抑制性T细胞在胸腺依赖性上的差异。
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9
Large numbers of cells in normal mice produce antibody components of isologous erythrocytes.正常小鼠中的大量细胞产生同种红细胞的抗体成分。
Nature. 1974 Dec 20;252(5485):749-51. doi: 10.1038/252749a0.
10
Regulatory T cells as central regulators of both autoimmunity and B cell malignancy in New Zealand Black mice.调节性T细胞作为新西兰黑鼠自身免疫和B细胞恶性肿瘤的核心调节因子。
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引用本文的文献

1
Equal distribution of T-lymphocyte subpopulations in thymus and spleen cells of NZB and BALB/c mice.NZB和BALB/c小鼠胸腺和脾细胞中T淋巴细胞亚群的均匀分布。
Rheumatol Int. 1984;4(1):31-4. doi: 10.1007/BF00683882.
2
Interferon and natural killer cells in systemic lupus erythematosus.系统性红斑狼疮中的干扰素与自然杀伤细胞。
Clin Exp Immunol. 1982 Nov;50(2):246-52.